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    QC glutaminyl cyclase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828677, updated on 18-Sep-2024

    Summary

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    Official Symbol
    QC
    Official Full Name
    glutaminyl cyclase
    Primary source
    TAIR:AT4G25720
    Locus tag
    AT4G25720
    See related
    Araport:AT4G25720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GLUTAMINYL CYCLASE; ATQC; glutaminyl cyclase; GLUTAMINYL CYCLOTRANSFERASE; L73G19.100; L73G19_100; QCT
    Summary
    This locus encodes a protein with similarity to gamma-glutamylcyclotransferase that may be involved in catalyzing the formation of pyroglutate residue on proteins that have been post-translationally processed to reveal a glutamine at their N-terminus. Enzymatic assays to test the function of this protein were performed using a truncated form of the protein lacking a signal peptide that is most similar to the AT4G25720.1 protein model.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (13099812..13102594, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3A subunit Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene FtsJ-like methyltransferase family protein Neighboring gene RNA binding Plectin/S10 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions. Schilling S, et al. Biol Chem, 2007 Feb. PMID 17261077
    2. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001036639.3
    NM_001036640.1
    NM_001341762.1
    NM_001341763.1
    NM_118704.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    glutaminyl cyclase
    NP_001031716.1
    • glutaminyl cyclase (QC); FUNCTIONS IN: glutaminyl-peptide cyclotransferase activity, catalytic activity; INVOLVED IN: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine cyclotransferase (InterPro:IPR007788), Nitrous oxide reductase, N-terminal (InterPro:IPR011045); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031717.1
    • glutaminyl cyclase (QC); FUNCTIONS IN: glutaminyl-peptide cyclotransferase activity, catalytic activity; INVOLVED IN: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine cyclotransferase (InterPro:IPR007788), Nitrous oxide reductase, N-terminal (InterPro:IPR011045); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_567727.1
    • glutaminyl cyclase (QC); FUNCTIONS IN: glutaminyl-peptide cyclotransferase activity, catalytic activity; INVOLVED IN: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine cyclotransferase (InterPro:IPR007788), Nitrous oxide reductase, N-terminal (InterPro:IPR011045); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13099812..13102594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036640.1 → NP_001031717.1  glutaminyl cyclase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V139
      Conserved Domains (2) summary
      pfam05096
      Location:78 → 283
      Glu_cyclase_2; Glutamine cyclotransferase
      cl02567
      Location:149 → 275
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001036639.3 → NP_001031716.1  glutaminyl cyclase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V139
      Conserved Domains (1) summary
      pfam05096
      Location:78 → 289
      Glu_cyclase_2; Glutamine cyclotransferase

    3. NM_118704.2 → NP_567727.1  glutaminyl cyclase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V3F0, Q84WV9, Q8LFT4, Q9T000
      UniProtKB/TrEMBL
      A0A178V139, A0A5S9XW79, A0A654FSU2
      Conserved Domains (1) summary
      pfam05096
      Location:78 → 303
      Glu_cyclase_2; Glutamine cyclotransferase

    4. NM_001341762.1 → NP_001329256.1  glutaminyl cyclase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V1H7, A0A1P8B755

    5. NM_001341763.1 → NP_001329255.1  glutaminyl cyclase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V1H7, C0Z264
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84WV9.1

    Gene LinkOut

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