PAA1 P-type ATP-ase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PAA1
Official Full Name: P-type ATP-ase 1
Primary source: TAIR:AT4G33520
Locus tag: AT4G33520
See related: Araport:AT4G33520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana heavy metal ATPase 6; AtHMAC6; F17M5.280; F17M5_280; HEAVY METAL ATPASE 6; HMA6; P-type ATP-ase 1
Summary: Encodes a putative metal-transporting P-type ATPase.
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Genomic context

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See PAA1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 19

Sequence:: Chromosome: 4; NC_003075.7 (16118830..16126151)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structures of the nucleotide binding domain of HMA6 and HMA8 from Arabidopsis thaliana are reported at 1.5A and 1.75A resolution, respectively, providing the first structural information on plants Cu+-ATPases.
Title: Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana.
Combining functional and structural data, we highlight the importance of the cysteine and the first histidine of the CX3HX2H motif in the process of copper release from HMA6 and HMA8 and propose a copper pathway through the membrane domain of these transporters.
Title: Identification of Two Conserved Residues Involved in Copper Release from Chloroplast PIB-1-ATPases.
HMA6 enzymatic properties and affinity for Cu
Title: HMA6 and HMA8 are two chloroplast Cu+-ATPases with different enzymatic properties.
Plastid chaperone 1 (PCH1), which is produced as an alternative-splicing event of the PAA1 pre-mRNA, delivers Cu+ with specificity to PAA1.
Title: Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis.
HMA1 and PAA1 behave as distinct pathways for copper import and targeting to the chloroplast.
Title: HMA1 and PAA1, two chloroplast-envelope PIB-ATPases, play distinct roles in chloroplast copper homeostasis.
the plastidial Cu transporter PAA1, which is essential for plastid function and/or activity, plays an important role in bidirectional communication between the plastid and the nucleus in high glucose.
Title: Analysis of Arabidopsis glucose insensitive growth mutants reveals the involvement of the plastidial copper transporter PAA1 in glucose-induced intracellular signaling.
the first enzymatic characterization of a P(IB-1)-type plant ATPase and clearly identify PAA1 as a high affinity Cu(I) transporter of the chloroplast envelope.
Title: Biochemical characterization of AtHMA6/PAA1, a chloroplast envelope Cu(I)-ATPase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001342218.1

Supported by ESTs:

NM_119506.4

Supported by ESTs:

NM_202946.3

Supported by ESTs:

NM_202947.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type ion transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables P-type monovalent copper transporter activity	IEA Inferred from Electronic Annotation more info
enables copper chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within copper ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photosynthetic electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photosynthetic electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast envelope	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: P-type ATP-ase 1

NP_567924.1

P-type ATP-ase 1 (PAA1); FUNCTIONS IN: copper ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: photosynthetic electron transport chain; LOCATED IN: chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), Heavy-metal-associated, conserved site (InterPro:IPR017969); BEST Arabidopsis thaliana protein match is: P-type ATPase of Arabidopsis 2 (TAIR:AT5G21930.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974675.1

P-type ATP-ase 1 (PAA1); FUNCTIONS IN: copper ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: photosynthetic electron transport chain; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type copper-transporter (InterPro:IPR001756), Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Heavy-metal-associated, conserved site (InterPro:IPR017969), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: P-type ATPase of Arabidopsis 2 (TAIR:AT5G21930.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_974676.1

P-type ATP-ase 1 (PAA1); FUNCTIONS IN: copper ion transmembrane transporter activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: photosynthetic electron transport chain; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type copper-transporter (InterPro:IPR001756), Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Heavy-metal-associated, conserved site (InterPro:IPR017969), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: P-type ATPase of Arabidopsis 2 (TAIR:AT5G21930.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16118830..16126151

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202946.3 → NP_974675.1 P-type ATP-ase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974675.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48600, O81870, Q0WPL5, Q93YP5, Q9SZC9

UniProtKB/TrEMBL

A0A5S9XYN0

Conserved Domains (2) summary

cd00371
Location:152 → 207

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

cd02079
Location:253 → 914

P-type_ATPase_HM; P-type heavy metal-transporting ATPase
NM_119506.4 → NP_567924.1 P-type ATP-ase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567924.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V4T2

Conserved Domains (1) summary

cd00371
Location:152 → 207

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
NM_202947.1 → NP_974676.1 P-type ATP-ase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974676.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XYN0, F4JIZ4

Conserved Domains (4) summary

COG2217
Location:152 → 919

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:736 → 820

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:152 → 207

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:352 → 587

E1-E2_ATPase; E1-E2 ATPase
NM_001342218.1 → NP_001328919.1 P-type ATP-ase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B649