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    ADC2 arginine decarboxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829623, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADC2
    Official Full Name
    arginine decarboxylase 2
    Primary source
    TAIR:AT4G34710
    Locus tag
    AT4G34710
    See related
    Araport:AT4G34710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGININE DECARBOXYLASE; arginine decarboxylase 2; ATADC2; SPE2; T4L20.290; T4L20_290
    Summary
    encodes a arginine decarboxylase (ADC), a rate-limiting enzyme that catalyzes the first step of polyamine (PA) biosynthesis via ADC pathway in Arabidopsis thaliana. Arabidopsis genome has two ADC paralogs, ADC1 and ADC2. ADC2 is stress-inducible (osmotic stress). Double mutant analysis showed that ADC genes are essential for the production of PA, and are required for normal seed development. Overexpression causes phenotypes similar to GA-deficient plants and these plants show reduced levels of GA due to lower expression levels of AtGA20ox1, AtGA3ox3 and AtGA3ox1.
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    Genomic context

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    See ADC2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (16560030..16563044, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene LYR family of Fe/S cluster biogenesis protein Neighboring gene ncRNA Neighboring gene ATPase, F0/V0 complex, subunit C protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putrescine accumulation confers drought tolerance in transgenic Arabidopsis plants over-expressing the homologous Arginine decarboxylase 2 gene. Alcázar R, et al. Plant Physiol Biochem, 2010 Jul. PMID 20206537
    2. Induction of the arginine decarboxylase ADC2 gene provides evidence for the involvement of polyamines in the wound response in Arabidopsis. Perez-Amador MA, et al. Plant Physiol, 2002 Nov. PMID 12428010, Free PMC Article
    3. Arabidopsis knockout mutation of ADC2 gene reveals inducibility by osmotic stress. Soyka S, et al. FEBS Lett, 1999 Sep 17. PMID 10481069
    4. Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2. Maruri-López I, et al. Biochem Biophys Res Commun, 2017 Mar 11. PMID 28109885
    5. Simultaneous Silencing of Two Arginine Decarboxylase Genes Alters Development in Arabidopsis. Sánchez-Rangel D, et al. Front Plant Sci, 2016. PMID 27014322, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reveals that both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other.
      Title: Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2.
    2. ADC2 had a major contribution of to total arginine decarboxylase (ADC) activity and the specific induction of ADC1 in response to infection.
      Title: Role of Arginine decarboxylase (ADC) in Arabidopsis thaliana defence against the pathogenic bacterium Pseudomonas viridiflava.
    3. a reduction in transpiration rate and stomata conductance was observed in the ADC2 over-expressor lines.
      Title: Putrescine accumulation confers drought tolerance in transgenic Arabidopsis plants over-expressing the homologous Arginine decarboxylase 2 gene.
    4. Arginine decarboxylase genes are required for production of polyamines that are essential for normal seed development in Arabidopsis
      Title: Arabidopsis ADC genes involved in polyamine biosynthesis are essential for seed development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119637.3
    NM_202955.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arginine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    arginine decarboxylase 2
    NP_195197.1
    • arginine decarboxylase 2 (ADC2); CONTAINS InterPro DOMAIN/s: Orn/DAP/Arg decarboxylase 2, C-terminal (InterPro:IPR022643), Orn/DAP/Arg decarboxylase 2, conserved site (InterPro:IPR022657), Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (InterPro:IPR022653), Ornithine/DAP/Arg decarboxylase (InterPro:IPR000183), Arginine decarboxylase (InterPro:IPR002985), Orn/DAP/Arg decarboxylase 2, N-terminal (InterPro:IPR022644); BEST Arabidopsis thaliana protein match is: arginine decarboxylase 1 (TAIR:AT2G16500.1); Has 7853 Blast hits to 7777 proteins in 2122 species: Archae - 112; Bacteria - 5255; Metazoa - 102; Fungi - 32; Plants - 645; Viruses - 2; Other Eukaryotes - 1705 (source: NCBI BLink).
    NP_974684.1
    • arginine decarboxylase 2 (ADC2); CONTAINS InterPro DOMAIN/s: Orn/DAP/Arg decarboxylase 2, C-terminal (InterPro:IPR022643), Orn/DAP/Arg decarboxylase 2, conserved site (InterPro:IPR022657), Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (InterPro:IPR022653), Ornithine/DAP/Arg decarboxylase (InterPro:IPR000183), Arginine decarboxylase (InterPro:IPR002985), Orn/DAP/Arg decarboxylase 2, N-terminal (InterPro:IPR022644); BEST Arabidopsis thaliana protein match is: arginine decarboxylase 1 (TAIR:AT2G16500.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16560030..16563044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119637.3 → NP_195197.1  arginine decarboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195197.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23141, Q8H165, Q93ZG4
      UniProtKB/TrEMBL
      A0A178V3H1, A0A5S9XYQ1, A0A654FVJ1
      Conserved Domains (1) summary
      PLN02439
      Location:108 → 680
      PLN02439; arginine decarboxylase

    2. NM_202955.1 → NP_974684.1  arginine decarboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23141, Q8H165, Q93ZG4
      UniProtKB/TrEMBL
      A0A178V3H1, A0A5S9XYQ1, A0A654FVJ1
      Conserved Domains (1) summary
      PLN02439
      Location:108 → 680
      PLN02439; arginine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23141.1

    Gene LinkOut

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