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    ELI3-2 cinnamyl alcohol dehydrogenase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829955, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ELI3-2
    Official Full Name
    cinnamyl alcohol dehydrogenase 8
    Primary source
    TAIR:AT4G37990
    Locus tag
    AT4G37990
    See related
    Araport:AT4G37990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CINNAMYL-ALCOHOL DEHYDROGENASE 8; ATCAD8; CAD-B2; CI0009; CINNAMYL-ALCOHOL DEHYDROGENASE; CINNAMYL-ALCOHOL DEHYDROGENASE B2; ELI3; ELICITOR-ACTIVATED GENE 3; elicitor-activated gene 3-2; F20D10.110; F20D10_110
    Summary
    Encodes an aromatic alcohol:NADP+ oxidoreductase whose mRNA levels are increased in response to treatment with a variety of phytopathogenic bacteria. Though similar to mannitol dehydrogenases, this enzyme does not have mannitol dehydrogenase activity.
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    Genomic context

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    See ELI3-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (17855637..17857878)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene cinnamyl alcohol dehydrogenase 6 Neighboring gene cinnamyl alcohol dehydrogenase 7 Neighboring gene DNA binding with one finger 4.7 Neighboring gene uncharacterized protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana defense-related protein ELI3 is an aromatic alcohol:NADP+ oxidoreductase. Somssich IE, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 11038530, Free PMC Article
    2. Rapid activation of a novel plant defense gene is strictly dependent on the Arabidopsis RPM1 disease resistance locus. Kiedrowski S, et al. EMBO J, 1992 Dec. PMID 1464303, Free PMC Article
    3. Expression of cinnamyl alcohol dehydrogenases and their putative homologues during Arabidopsis thaliana growth and development: lessons for database annotations? Kim SJ, et al. Phytochemistry, 2007 Jul. PMID 17467016
    4. Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis. Kim SJ, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745009, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_119960.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aryl-alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cinnamyl-alcohol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cinnamyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables mannitol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lignin biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    cinnamyl alcohol dehydrogenase 8
    NP_195512.1
    • elicitor-activated gene 3-2 (ELI3-2); CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: elicitor-activated gene 3-1 (TAIR:AT4G37980.1); Has 39982 Blast hits to 39962 proteins in 3075 species: Archae - 828; Bacteria - 26485; Metazoa - 1263; Fungi - 3046; Plants - 3202; Viruses - 3; Other Eukaryotes - 5155 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17855637..17857878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119960.3 → NP_195512.1  cinnamyl alcohol dehydrogenase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02972, Q53ZN2
      UniProtKB/TrEMBL
      A0A178UVK9, A0A5S9XZX2
      Conserved Domains (1) summary
      cd05283
      Location:10 → 348
      CAD1; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02972.1

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