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    FLN1 fructokinase-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824576, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLN1
    Official Full Name
    fructokinase-like 1
    Primary source
    TAIR:AT3G54090
    Locus tag
    AT3G54090
    See related
    Araport:AT3G54090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    fructokinase-like 1
    Summary
    Encodes a fructokinase-like protein (AT3G54090/FLN1, AT1G69200/FLN2), a member of the pfkB-carbohydrate kinase family. FLN1 and FLN2 are potential plastidial thioredoxin z (TRX z) targets. Mutants display mutant chloroplast development, general plant growth and development defects and defects in PEP-dependent transcription.
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    Genomic context

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    See FLN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (20028052..20030055)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Concanavalin A-like lectin family protein Neighboring gene ncRNA Neighboring gene Yos1-like protein Neighboring gene ncRNA Neighboring gene O-fucosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis fructokinase-like protein associations are regulated by ATP. Riggs JW, et al. Biochem J, 2017 May 10. PMID 28377494
    2. Redox activity of thioredoxin z and fructokinase-like protein 1 is dispensable for autotrophic growth of Arabidopsis thaliana. Wimmelbacher M, et al. J Exp Bot, 2014 Jun. PMID 24659486, Free PMC Article
    3. The plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 are essential for growth and development of Arabidopsis thaliana. Gilkerson J, et al. BMC Plant Biol, 2012 Jul 8. PMID 22770232, Free PMC Article
    4. The reduced plastid-encoded polymerase-dependent plastid gene expression leads to the delayed greening of the Arabidopsis fln2 mutant. Huang C, et al. PLoS One, 2013. PMID 24019900, Free PMC Article
    5. TAC7, an essential component of the plastid transcriptionally active chromosome complex, interacts with FLN1, TAC10, TAC12 and TAC14 to regulate chloroplast gene expression in Arabidopsis thaliana. Yu QB, et al. Physiol Plant, 2013 Jul. PMID 23082802

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that, at ATP concentrations that promote FLN1 homomeric interactions, the FLN1-FLN2 hetero-oligomer is dominant form in vitro; FLN1 associates with a large protein complex in chloroplasts independent of ATP.
      Title: Arabidopsis fructokinase-like protein associations are regulated by ATP.
    2. Redox activity of TRXz and FLN1 is dispensable for autotrophic growth.
      Title: Redox activity of thioredoxin z and fructokinase-like protein 1 is dispensable for autotrophic growth of Arabidopsis thaliana.
    3. TAC7 can interact with the four TAC components including FLN1, TAC10, TAC12 and TAC14 which are involved in redox state changes, phosphorylation processes and phytochrome-dependent light signaling.
      Title: TAC7, an essential component of the plastid transcriptionally active chromosome complex, interacts with FLN1, TAC10, TAC12 and TAC14 to regulate chloroplast gene expression in Arabidopsis thaliana.
    4. FLN1 and FLN2 are essential for growth and development.
      Title: The plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 are essential for growth and development of Arabidopsis thaliana.
    5. Data strongly suggests an important role for TRX z and both FLNs in the regulation of plastid-encoded RNA polymerase-dependent transcription in chloroplasts. [FLN1]
      Title: Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115269.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plastid transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast nucleoid HDA PubMed 
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    fructokinase-like 1
    NP_190977.1
    • fructokinase-like 1 (FLN1); FUNCTIONS IN: kinase activity; INVOLVED IN: acetate fermentation, sucrose biosynthetic process, sucrose catabolic process, using beta-fructofuranosidase; LOCATED IN: chloroplast nucleoid, nucleus, chloroplast, nucleoid, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173); BEST Arabidopsis thaliana protein match is: fructokinase-like 2 (TAIR:AT1G69200.1); Has 4776 Blast hits to 4772 proteins in 1393 species: Archae - 92; Bacteria - 3898; Metazoa - 5; Fungi - 2; Plants - 280; Viruses - 0; Other Eukaryotes - 499 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20028052..20030055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115269.4 → NP_190977.1  fructokinase-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M394
      UniProtKB/TrEMBL
      A0A178V7L2, A0A5S9XLF5, A0A654FFM3
      Conserved Domains (1) summary
      PLN02543
      Location:1 → 471
      PLN02543; pfkB-type carbohydrate kinase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M394.1

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