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    CXIP1 CAX interacting protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824655, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CXIP1
    Official Full Name
    CAX interacting protein 1
    Primary source
    TAIR:AT3G54900
    Locus tag
    AT3G54900
    See related
    Araport:AT3G54900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGRXCP; CAX interacting protein 1; GLUTAREDOXIN
    Summary
    A.thaliana PICOT protein.It activates CAX1 gene Calcium transport activity.In other organisms, PICOT proteins appear to play a negative regulatory role in cellular stress responses.
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    Genomic context

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    See CXIP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (20341357..20342464, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Armadillo/beta-catenin repeat family protein / kinesin motor family protein Neighboring gene zinc finger protein Neighboring gene chlorophyll a-b binding protein 6 Neighboring gene RNI-like superfamily protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp. Li L, et al. Acta Crystallogr D Biol Crystallogr, 2010 Jun. PMID 20516625, Free PMC Article
    2. AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage. Cheng NH, et al. J Biol Chem, 2006 Sep 8. PMID 16829529
    3. Involvement of Arabidopsis glutaredoxin S14 in the maintenance of chlorophyll content. Rey P, et al. Plant Cell Environ, 2017 Oct. PMID 28741719
    4. Structural and spectroscopic insights into BolA-glutaredoxin complexes. Roret T, et al. J Biol Chem, 2014 Aug 29. PMID 25012657, Free PMC Article
    5. Cloning and characterization of CXIP1, a novel PICOT domain-containing Arabidopsis protein that associates with CAX1. Cheng NH, et al. J Biol Chem, 2003 Feb 21. PMID 12480930

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data revealed that GRXS14 and GRXS16 play important roles in the control of vegetative growth and that GRXS14 possesses specific functions in the maintenance of chlorophyll content depending on environmental and light conditions. [GRXS14]
      Title: Involvement of Arabidopsis glutaredoxin S14 in the maintenance of chlorophyll content.
    2. AtGRXcp has a glutaredoxin/thioredoxin-like fold with distinct structural features that differ from those of dithiol glutaredoxins.
      Title: Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp.
    3. Results describe the initial functional characterization of a plant monothiol Glutaredoxin and suggests a conserved biological function in protecting cells against protein oxidative damage [AtGRXcp].
      Title: AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115347.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione disulfide oxidoreductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    CAX interacting protein 1
    NP_191050.1
    • CAX interacting protein 1 (CXIP1); FUNCTIONS IN: antiporter activity, glutathione disulfide oxidoreductase activity; INVOLVED IN: cation transport; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutaredoxin (InterPro:IPR002109), Thioredoxin-like fold (InterPro:IPR012336), Glutaredoxin-related protein (InterPro:IPR004480); BEST Arabidopsis thaliana protein match is: thioredoxin family protein (TAIR:AT4G04950.1); Has 5270 Blast hits to 5080 proteins in 1299 species: Archae - 26; Bacteria - 2196; Metazoa - 419; Fungi - 285; Plants - 426; Viruses - 0; Other Eukaryotes - 1918 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20341357..20342464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115347.4 → NP_191050.1  CAX interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84Y95, Q9SV38
      UniProtKB/TrEMBL
      A0A178VNB8, A0A654FH53
      Conserved Domains (1) summary
      cd03028
      Location:75 → 164
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84Y95.2

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