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    HDG1 homeodomain GLABROUS 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825287, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HDG1
    Official Full Name
    homeodomain GLABROUS 1
    Primary source
    TAIR:AT3G61150
    Locus tag
    AT3G61150
    See related
    Araport:AT3G61150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HD-GL2-1; homeodomain GLABROUS 1; HOMEODOMAIN-GLABRA2 1
    Summary
    Encodes a homeobox-leucine zipper family protein belonging to the HD-ZIP IV family.
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    Genomic context

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    See HDG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (22630331..22635155)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene galacturonosyltransferase 1 Neighboring gene COP9 signalosome complex subunit 1 Neighboring gene Protein kinase superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene low-molecular-weight cysteine-rich 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis. Wu R, et al. Plant Cell, 2011 Sep. PMID 21954461, Free PMC Article
    2. Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein. Shaikhali J, et al. Biochem J, 2015 Jun 15. PMID 25877331
    3. Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana. Kamata N, et al. Plant J, 2013 Aug. PMID 23590515
    4. AIL and HDG proteins act antagonistically to control cell proliferation. Horstman A, et al. Development, 2015 Feb 1. PMID 25564655
    5. Transcriptional regulation of nitrogen-associated metabolism and growth. Gaudinier A, et al. Nature, 2018 Nov. PMID 30356219

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that presence of mediator complex subunits MED10a, MED28, and MED32 or changes in redox state affect DNA-binding capacity of GeBPL (GLABROUS1/GL1 enhancer-binding protein-like) at likely GLABROUS1/GL1 promoter.
      Title: Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein.
    2. Rice and Arabidopsis CFL1 negatively regulate cuticle development by affecting the function of HDG1, which regulates the downstream genes BDG and FDH.
      Title: CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115979.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral organ identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain GLABROUS 1
    NP_191674.1
    • homeodomain GLABROUS 1 (HDG1); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT4G00730.1); Has 11756 Blast hits to 11371 proteins in 530 species: Archae - 0; Bacteria - 4; Metazoa - 8768; Fungi - 189; Plants - 2580; Viruses - 0; Other Eukaryotes - 215 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22630331..22635155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115979.5 → NP_191674.1  homeodomain GLABROUS 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191674.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LFW5, Q9M2E8
      UniProtKB/TrEMBL
      A0A178V5Q4, A0A7G2EUF5
      Conserved Domains (3) summary
      cd08875
      Location:314 → 537
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      COG5576
      Location:69 → 185
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:113 → 166
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2E8.1

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