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    FRA1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834833, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRA1
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT5G47820
    Locus tag
    AT5G47820
    See related
    Araport:AT5G47820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FRAGILE FIBER 1; MCA23.16; MCA23_16
    Summary
    encodes a kinesin-like protein with an N-terminal microtubule binding motor domain. Protein is localized to the periphery of the cytoplasm and mutants in the gene exhibit altered orientation of cellulose microfibrils and reduced mechanical strength of fibers.
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    Genomic context

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    See FRA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Sequence:
    Chromosome: 5; NC_003076.8 (19366133..19372815)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene adenosine monophosphate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly. Ganguly A, et al. J Cell Sci, 2017 Apr 1. PMID 28219953
    2. The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components. Zhu C, et al. Plant Physiol, 2015 Mar. PMID 25646318, Free PMC Article
    3. Single molecule analysis of the Arabidopsis FRA1 kinesin shows that it is a functional motor protein with unusually high processivity. Zhu C, et al. Mol Plant, 2011 Sep. PMID 21914648
    4. A kinesin-like protein is essential for oriented deposition of cellulose microfibrils and cell wall strength. Zhong R, et al. Plant Cell, 2002 Dec. PMID 12468730, Free PMC Article
    5. Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants. Kong Z, et al. Mol Plant, 2015 Jul. PMID 25600279

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRA1 Kinesin Modulates the Lateral Stability of Cortical Microtubules through Cellulose Synthase-Microtubule Uncoupling Proteins.
      Title: FRA1 Kinesin Modulates the Lateral Stability of Cortical Microtubules through Cellulose Synthase-Microtubule Uncoupling Proteins.
    2. a high density of processive motility is necessary for the physiological function of FRA1.
      Title: The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly.
    3. FRA1 contributes to cell wall production by transporting Golgi-derived vesicles along cortical microtubules for secretion.
      Title: The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components.
    4. FRA1 is a functional motor protein to drive long-distance transport of cargo along cortical microtubules.
      Title: Single molecule analysis of the Arabidopsis FRA1 kinesin shows that it is a functional motor protein with unusually high processivity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_124156.5
    NM_180820.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellulose microfibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton-dependent intracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_199593.2
    • FRAGILE FIBER 1 (FRA1); CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851151.1
    • FRAGILE FIBER 1 (FRA1); CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G50240.1); Has 53631 Blast hits to 37823 proteins in 1811 species: Archae - 386; Bacteria - 4938; Metazoa - 26865; Fungi - 4658; Plants - 3439; Viruses - 113; Other Eukaryotes - 13232 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19366133..19372815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180820.2 → NP_851151.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GS71, Q9FIJ9
      UniProtKB/TrEMBL
      A0A178UKL3, A0A5S9YC94, A0A654G9H8
      Conserved Domains (2) summary
      COG0419
      Location:490 → 912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:10 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    2. NM_124156.5 → NP_199593.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199593.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GS71, Q9FIJ9
      UniProtKB/TrEMBL
      A0A178UKL3, A0A5S9YC94, A0A654G9H8
      Conserved Domains (2) summary
      COG0419
      Location:490 → 912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:10 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GS71.1

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