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    Transcriptional coactivator/pterin dehydratase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835185, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Transcriptional coactivator/pterin dehydratase
    Primary source
    TAIR:AT5G51110
    Locus tag
    AT5G51110
    See related
    Araport:AT5G51110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MWD22.5; MWD22_5
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (20777501..20779488, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fe superoxide dismutase 2 Neighboring gene ECA1 gametogenesis family protein (DUF1278) Neighboring gene polyadenylate-binding protein 1 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Pseudouridine synthase family protein Neighboring gene Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAF2 is a RuBisCO assembly factor in Arabidopsis thaliana. Fristedt R, et al. Plant J, 2018 Apr. PMID 29396988
    2. AtAIRP2 E3 Ligase Affects ABA and High-Salinity Responses by Stimulating Its ATP1/SDIRIP1 Substrate Turnover. Oh TR, et al. Plant Physiol, 2017 Aug. PMID 28626006, Free PMC Article
    3. The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING PROTEIN1 for degradation to modulate the salt stress response and ABA signaling in Arabidopsis. Zhang H, et al. Plant Cell, 2015 Jan. PMID 25616872, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAF2 is probably involved in RuBisCO assembly. [RAF2]
      Title: RAF2 is a RuBisCO assembly factor in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203581.1
    NM_124490.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribulose bisphosphate carboxylase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Transcriptional coactivator/pterin dehydratase
    NP_001190510.1
    • Transcriptional coactivator/pterin dehydratase; FUNCTIONS IN: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; INVOLVED IN: tetrahydrobiopterin biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcriptional coactivator/pterin dehydratase (InterPro:IPR001533); BEST Arabidopsis thaliana protein match is: Transcriptional coactivator/pterin dehydratase (TAIR:AT1G29810.1).
    NP_199924.1
    • Transcriptional coactivator/pterin dehydratase; FUNCTIONS IN: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; INVOLVED IN: tetrahydrobiopterin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcriptional coactivator/pterin dehydratase (InterPro:IPR001533); BEST Arabidopsis thaliana protein match is: Transcriptional coactivator/pterin dehydratase (TAIR:AT1G29810.1); Has 1849 Blast hits to 1849 proteins in 364 species: Archae - 43; Bacteria - 697; Metazoa - 0; Fungi - 2; Plants - 93; Viruses - 0; Other Eukaryotes - 1014 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20777501..20779488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124490.5 → NP_199924.1  Transcriptional coactivator/pterin dehydratase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199924.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GZ70, Q8L944, Q9LU63
      UniProtKB/TrEMBL
      A0A178UCR6, A0A5S9YD32
      Conserved Domains (1) summary
      cd00913
      Location:128 → 207
      PCD_DCoH_subfamily_a; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

    2. NM_001203581.1 → NP_001190510.1  Transcriptional coactivator/pterin dehydratase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KBV0
      Conserved Domains (1) summary
      cd00913
      Location:101 → 180
      PCD_DCoH_subfamily_a; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU63.1

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