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    CBF4 C-repeat-binding factor 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835274, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBF4
    Official Full Name
    C-repeat-binding factor 4
    Primary source
    TAIR:AT5G51990
    Locus tag
    AT5G51990
    See related
    Araport:AT5G51990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    C-repeat-binding factor 4; DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 1D; DREB1D; MSG15.8; MSG15_8
    Summary
    encodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (CBF4). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. This gene is involved in response to drought stress and abscisic acid treatment, but not to low temperature.
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    Genomic context

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    See CBF4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (21116877..21117860, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene complex 1 protein, LYR family protein Neighboring gene GroES-like zinc-binding alcohol dehydrogenase family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene importin alpha isoform 8 Neighboring gene C2H2-like zinc finger protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis. Haake V, et al. Plant Physiol, 2002 Oct. PMID 12376631, Free PMC Article
    2. Vascular plant one-zinc-finger protein 1/2 transcription factors regulate abiotic and biotic stress responses in Arabidopsis. Nakai Y, et al. Plant J, 2013 Mar. PMID 23167462
    3. AtMYB32 regulates the ABA response by targeting ABI3, ABI4 and ABI5 and the drought response by targeting CBF4 in Arabidopsis. Li X, et al. Plant Sci, 2021 Sep. PMID 34315599
    4. Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors. Sparks EE, et al. Dev Cell, 2016 Dec 5. PMID 27923776, Free PMC Article
    5. The TOPLESS interactome: a framework for gene repression in Arabidopsis. Causier B, et al. Plant Physiol, 2012 Jan. PMID 22065421, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMYB32 regulates the ABA response by targeting ABI3, ABI4 and ABI5 and the drought response by targeting CBF4 in Arabidopsis.
      Title: AtMYB32 regulates the ABA response by targeting ABI3, ABI4 and ABI5 and the drought response by targeting CBF4 in Arabidopsis.
    2. Vascular plant one-zinc-finger proteins (VOZs) negatively affect CBF4 expression in an activating abscisic acid-mediated (ABA)-independent manner.
      Title: Vascular plant one-zinc-finger protein 1/2 transcription factors regulate abiotic and biotic stress responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124578.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    C-repeat-binding factor 4
    NP_200012.1
    • C-repeat-binding factor 4 (CBF4); FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to water deprivation, regulation of transcription, DNA-dependent, response to abscisic acid stimulus; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: stem, root, pedicel, carpel; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: C-repeat/DRE binding factor 2 (TAIR:AT4G25470.1); Has 5782 Blast hits to 5666 proteins in 248 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5775; Viruses - 2; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21116877..21117860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124578.2 → NP_200012.1  C-repeat-binding factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MFN5, Q1PDK4, Q6J9R8, Q9FJ93
      UniProtKB/TrEMBL
      A0A178ULT7, A0A654GB52, B2BJ25, B2BJ26, B2BJ27
      Conserved Domains (1) summary
      cd00018
      Location:52 → 112
      AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJ93.1

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