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    Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 18212, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ntrk2provided by MGI
    Official Full Name
    neurotrophic tyrosine kinase, receptor, type 2provided by MGI
    Primary source
    MGI:MGI:97384
    See related
    Ensembl:ENSMUSG00000055254 AllianceGenome:MGI:97384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
    Summary
    Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and terminal bouton. Is expressed in several structures, including alimentary system; future brain; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.3), cortex adult (RPKM 10.2) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ntrk2 in Genome Data Viewer
    Location:
    13 B1; 13 31.2 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58954363..59281782)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58806472..59133970)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455J16 gene Neighboring gene ribosomal protein L13, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_34694 Neighboring gene predicted gene, 40968 Neighboring gene STARR-seq mESC enhancer starr_34695 Neighboring gene STARR-seq mESC enhancer starr_34698 Neighboring gene STARR-seq mESC enhancer starr_34699 Neighboring gene STARR-seq mESC enhancer starr_34701 Neighboring gene VISTA enhancer mm14 Neighboring gene predicted gene 53063 Neighboring gene STARR-seq mESC enhancer starr_34702 Neighboring gene predicted gene, 34245 Neighboring gene STARR-seq mESC enhancer starr_34703 Neighboring gene STARR-seq mESC enhancer starr_34704 Neighboring gene predicted gene, 34307 Neighboring gene predicted gene, 34354 Neighboring gene STARR-seq mESC enhancer starr_34705 Neighboring gene predicted gene, 34558

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • C030027L06Rik

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor binding  
    enables brain-derived neurotrophic factor binding PubMed 
    enables brain-derived neurotrophic factor binding  
    enables brain-derived neurotrophic factor receptor activity  
    enables brain-derived neurotrophic factor receptor activity PubMed 
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables neurotrophin binding PubMed 
    enables neurotrophin binding  
    enables neurotrophin binding  
    enables neurotrophin receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables receptor tyrosine kinase binding  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 35
    Items 1 - 25 of 72
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cellular response to amino acid stimulus PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus  
    involved_in central nervous system neuron development PubMed 
    involved_in cerebral cortex development PubMed 
    involved_in chromatin remodeling  
    involved_in circadian rhythm PubMed 
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within feeding behavior PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within glutamate secretion PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in learning PubMed 
    involved_in long-term memory  
    involved_in long-term synaptic potentiation PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within mechanoreceptor differentiation PubMed 
    involved_in multicellular organism development  
    acts_upstream_of_or_within myelination in peripheral nervous system PubMed 
    involved_in negative regulation of amyloid-beta formation  
    acts_upstream_of_or_within negative regulation of amyloid-beta formation  
    involved_in negative regulation of anoikis PubMed 
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of neuron apoptotic process  
    involved_in neuron differentiation PubMed 
    involved_in neuron migration PubMed 
    acts_upstream_of_or_within neuronal action potential propagation PubMed 
    involved_in neurotrophin signaling pathway  
    involved_in oligodendrocyte differentiation PubMed 
    acts_upstream_of peptidyl-serine phosphorylation PubMed 
    involved_in peripheral nervous system neuron development PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of axonogenesis  
    involved_in positive regulation of axonogenesis  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of synapse assembly PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic  
    involved_in protein autophosphorylation  
    involved_in regulation of GTPase activity PubMed 
    involved_in regulation of MAPK cascade  
    involved_in regulation of dendrite development  
    acts_upstream_of_or_within regulation of metabolic process PubMed 
    involved_in regulation of neurotransmitter secretion  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within retina development in camera-type eye PubMed 
    acts_upstream_of_or_within retinal rod cell development PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission PubMed 
    involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    acts_upstream_of_or_within vasculogenesis PubMed 
    Items 1 - 25 of 72
    Items 1 - 20 of 33
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon  
    is_active_in axon terminus  
    located_in axon terminus  
    located_in cell surface  
    located_in cytosol PubMed 
    located_in dendrite  
    located_in dendrite  
    is_active_in dendritic spine  
    located_in dendritic spine  
    located_in early endosome PubMed 
    located_in early endosome membrane  
    located_in endosome PubMed 
    located_in excitatory synapse  
    is_active_in glutamatergic synapse  
    located_in growth cone  
    located_in neuronal cell body  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    is_active_in postsynaptic density  
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic membrane  
    located_in presynaptic active zone  
    part_of receptor complex  
    part_of receptor complex PubMed 
    located_in terminal bouton PubMed 
    Items 1 - 20 of 33

    General protein information

    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    neurotrophic tyrosine receptor kinase type 2
    trkB tyrosine kinase
    NP_001020245.1
    NP_001269890.1
    NP_001413233.1
    NP_001413235.1
    NP_001413236.1
    NP_001413237.1
    NP_001413238.1
    NP_032771.1
    XP_006517212.1
    XP_006517214.1
    XP_030103049.1
    XP_036013804.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025074.3NP_001020245.1  BDNF/NT-3 growth factors receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001020245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC154755, AC159195
      Consensus CDS
      CCDS26573.1
      UniProtKB/Swiss-Prot
      P15209, Q3TUF9, Q80WU0, Q91XJ9
      Related
      ENSMUSP00000078757.6, ENSMUST00000079828.7
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    2. NM_001282961.2NP_001269890.1  BDNF/NT-3 growth factors receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001269890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AC154755, AC159195
      Consensus CDS
      CCDS26573.1
      UniProtKB/Swiss-Prot
      P15209, Q3TUF9, Q80WU0, Q91XJ9
      Related
      ENSMUSP00000153553.2, ENSMUST00000225488.2
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    3. NM_001426304.1NP_001413233.1  BDNF/NT-3 growth factors receptor isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC159195
      UniProtKB/TrEMBL
      A0A286YDA0, Q3UHE3
    4. NM_001426306.1NP_001413235.1  BDNF/NT-3 growth factors receptor isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC159195
      UniProtKB/TrEMBL
      A0A286YDA0, Q3UHE3
    5. NM_001426307.1NP_001413236.1  BDNF/NT-3 growth factors receptor isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC159195
      UniProtKB/TrEMBL
      A0A286YDA0, Q3UHE3
      Related
      ENSMUSP00000105464.3, ENSMUST00000109838.10
    6. NM_001426308.1NP_001413237.1  BDNF/NT-3 growth factors receptor isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC154755, AC159195
      UniProtKB/TrEMBL
      A0A286YDA0
    7. NM_001426309.1NP_001413238.1  BDNF/NT-3 growth factors receptor isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC154755, AC159195
      UniProtKB/TrEMBL
      A0A286YDA0
    8. NM_008745.4NP_032771.1  BDNF/NT-3 growth factors receptor isoform b precursor

      See identical proteins and their annotated locations for NP_032771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC159195
      Consensus CDS
      CCDS36685.1
      UniProtKB/TrEMBL
      A0A286YDA0, Q3UHE3
      Related
      ENSMUSP00000153270.2, ENSMUST00000224259.2
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      cl02423
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl11960
      Location:205283
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      58954363..59281782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157911.1XP_036013804.1  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/TrEMBL
      A0A286YDA0, A0A286YDA3
      Conserved Domains (7) summary
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    2. XM_006517149.5XP_006517212.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_006517212.1

      UniProtKB/Swiss-Prot
      P15209, Q3TUF9, Q80WU0, Q91XJ9
      Conserved Domains (5) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    3. XM_030247189.2XP_030103049.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/TrEMBL
      A0A286YDA0, Q3UHE3
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      cl02423
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
    4. XM_006517151.5XP_006517214.1  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/TrEMBL
      A0A286YDA0, A0A286YDA3
      Related
      ENSMUSP00000153333.2, ENSMUST00000224402.2
      Conserved Domains (7) summary
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      pfam16920
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:205209
      Ig; Ig strand A' [structural motif]
      cd05855
      Location:286379
      IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:205283
      Ig; Immunoglobulin domain
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