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    Mapk1 mitogen-activated protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 26413, updated on 4-Jan-2025

    Summary

    Official Symbol
    Mapk1provided by MGI
    Official Full Name
    mitogen-activated protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1346858
    See related
    Ensembl:ENSMUSG00000063358 AllianceGenome:MGI:1346858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik
    Summary
    Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; embryonic organ development; and respiratory system development. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mapk1 in Genome Data Viewer
    Location:
    16 A3; 16 10.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16801246..16865317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16983382..17047453)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9426 Neighboring gene predicted gene 6438 Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (14)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables JUN kinase activity  
    enables MAP kinase activity PubMed 
    enables MAP kinase activity PubMed 
    enables MAP kinase activity PubMed 
    enables RNA polymerase II CTD heptapeptide repeat kinase activity PubMed 
    enables double-stranded DNA binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables kinase activity PubMed 
    enables mitogen-activated protein kinase kinase kinase binding  
    enables phosphatase binding PubMed 
    enables phosphatase binding  
    enables phosphotyrosine residue binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 94
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell receptor signaling pathway PubMed 
    acts_upstream_of_or_within Bergmann glial cell differentiation PubMed 
    acts_upstream_of_or_within DNA damage response PubMed 
    involved_in DNA-templated transcription PubMed 
    involved_in ERBB signaling pathway  
    involved_in ERBB2-ERBB3 signaling pathway PubMed 
    acts_upstream_of_or_within ERK1 and ERK2 cascade PubMed 
    involved_in ERK1 and ERK2 cascade  
    involved_in JNK cascade  
    acts_upstream_of_or_within MAPK cascade PubMed 
    involved_in MAPK cascade PubMed 
    involved_in MAPK cascade  
    involved_in Schwann cell development PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway PubMed 
    involved_in androgen receptor signaling pathway  
    involved_in androgen receptor signaling pathway  
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in apoptotic process  
    acts_upstream_of_or_within cardiac neural crest cell development involved in heart development PubMed 
    involved_in caveolin-mediated endocytosis PubMed 
    involved_in cell surface receptor signaling pathway  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to cadmium ion  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to toxic substance  
    acts_upstream_of_or_within cellular response to tumor necrosis factor PubMed 
    acts_upstream_of_or_within cytosine metabolic process PubMed 
    involved_in decidualization  
    involved_in diadenosine tetraphosphate biosynthetic process  
    acts_upstream_of_or_within face development PubMed 
    acts_upstream_of_or_within face development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within labyrinthine layer blood vessel development PubMed 
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation PubMed 
    acts_upstream_of_or_within lung morphogenesis PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation PubMed 
    involved_in myelination PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation PubMed 
    acts_upstream_of_or_within neural crest cell development PubMed 
    acts_upstream_of_or_within outer ear morphogenesis PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cardiac muscle cell proliferation  
    involved_in positive regulation of cholesterol biosynthetic process  
    involved_in positive regulation of macrophage chemotaxis  
    acts_upstream_of positive regulation of macrophage chemotaxis  
    involved_in positive regulation of macrophage proliferation  
    acts_upstream_of positive regulation of macrophage proliferation  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of telomere capping  
    involved_in positive regulation of telomere maintenance  
    involved_in positive regulation of telomere maintenance via telomerase  
    involved_in positive regulation of translation  
    involved_in progesterone receptor signaling pathway  
    involved_in progesterone receptor signaling pathway  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of DNA-binding transcription factor activity PubMed 
    involved_in regulation of Golgi inheritance PubMed 
    acts_upstream_of_or_within regulation of cellular pH PubMed 
    involved_in regulation of cytoskeleton organization PubMed 
    involved_in regulation of early endosome to late endosome transport PubMed 
    acts_upstream_of_or_within regulation of ossification PubMed 
    involved_in regulation of protein stability  
    involved_in regulation of stress-activated MAPK cascade PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to epidermal growth factor  
    involved_in response to epidermal growth factor  
    involved_in response to estrogen  
    acts_upstream_of_or_within response to exogenous dsRNA PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to nicotine  
    involved_in response to toxic substance  
    involved_in sensory perception of pain  
    involved_in steroid hormone receptor signaling pathway  
    involved_in stress-activated MAPK cascade  
    involved_in stress-activated MAPK cascade  
    acts_upstream_of_or_within thymus development PubMed 
    acts_upstream_of_or_within thyroid gland development PubMed 
    acts_upstream_of_or_within trachea formation PubMed 
    Items 1 - 25 of 94
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in axon  
    located_in caveola  
    located_in caveola  
    located_in caveola PubMed 
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoskeleton PubMed 
    is_active_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in dendrite cytoplasm  
    located_in early endosome PubMed 
    located_in focal adhesion PubMed 
    located_in late endosome PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitotic spindle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus PubMed 
    located_in perikaryon  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    part_of protein-containing complex  
    located_in pseudopodium PubMed 
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    mitogen-activated protein kinase 1
    Names
    ERK-2
    ERT1
    MAP kinase 1
    MAP kinase 2
    MAPK 1
    MAPK 2
    extracellular signal-regulated kinase 2
    mitogen-activated protein kinase 2
    p42-MAPK
    NP_001033752.1
    NP_001344044.1
    NP_036079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038663.1NP_001033752.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_001033752.1

      Status: VALIDATED

      Source sequence(s)
      BB648734, D10939
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P27703, P63085, Q3V1U6
      UniProtKB/TrEMBL
      Q3UF82
      Related
      ENSMUSP00000111396.2, ENSMUST00000115731.10
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    2. NM_001357115.1NP_001344044.1  mitogen-activated protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      AC166346, AC166832
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P27703, P63085, Q3V1U6
      UniProtKB/TrEMBL
      Q3UF82
      Related
      ENSMUSP00000156154.2, ENSMUST00000232611.2
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    3. NM_011949.3NP_036079.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_036079.1

      Status: VALIDATED

      Source sequence(s)
      AC154667, AK132241, BB648734
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P27703, P63085, Q3V1U6
      UniProtKB/TrEMBL
      Q3UF82
      Related
      ENSMUSP00000065983.8, ENSMUST00000069107.14
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16801246..16865317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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