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    Rab8b RAB8B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 235442, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rab8bprovided by MGI
    Official Full Name
    RAB8B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2442982
    See related
    Ensembl:ENSMUSG00000036943 AllianceGenome:MGI:2442982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5930437D16; D330025I23Rik
    Summary
    Predicted to enable several functions, including GDP binding activity; GTPase activity; and TPR domain binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of corticotropin secretion; and protein import into peroxisome membrane. Located in mitochondrion. Is expressed in brain; liver; and small intestine. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.7), liver E14.5 (RPKM 13.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rab8b in Genome Data Viewer
    Location:
    9 C; 9 36.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66750891..66826987, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66843609..66919705, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E10560 Neighboring gene STARR-seq mESC enhancer starr_24481 Neighboring gene aph1 homolog C, gamma secretase subunit Neighboring gene STARR-positive B cell enhancer ABC_E8297 Neighboring gene predicted gene, 40528 Neighboring gene STARR-positive B cell enhancer ABC_E5081 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66767210-66767393 Neighboring gene STARR-positive B cell enhancer ABC_E5082 Neighboring gene STARR-seq mESC enhancer starr_24483 Neighboring gene ribosomal protein S27-like Neighboring gene lactamase, beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables TPR domain binding  
    enables TPR domain binding  
    enables protein binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    located_in cell tip  
    located_in cell tip  
    is_active_in endosome  
    located_in endosome membrane  
    located_in endosome membrane  
    located_in mitochondrion PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in peroxisomal membrane  
    located_in peroxisomal membrane  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in presynapse  
    is_active_in presynapse  
    is_active_in synaptic vesicle  
    is_active_in trans-Golgi network transport vesicle  

    General protein information

    Preferred Names
    ras-related protein Rab-8B
    Names
    RAB44, member RAS oncogene family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173413.3NP_775589.1  ras-related protein Rab-8B

      See identical proteins and their annotated locations for NP_775589.1

      Status: VALIDATED

      Source sequence(s)
      AC142504, BC059208, BY322741
      Consensus CDS
      CCDS23309.1
      UniProtKB/Swiss-Prot
      P61028, Q3U1Z3
      UniProtKB/TrEMBL
      Q0PD49
      Related
      ENSMUSP00000041857.8, ENSMUST00000041139.9
      Conserved Domains (1) summary
      cd01867
      Location:6172
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66750891..66826987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244336.2XP_030100196.1  ras-related protein Rab-8B isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:191
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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