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    Sac3d1 SAC3 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66406, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sac3d1provided by MGI
    Official Full Name
    SAC3 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1913656
    See related
    Ensembl:ENSMUSG00000024790 AllianceGenome:MGI:1913656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    shd1; 2410004C24Rik
    Summary
    Acts upstream of or within microtubule cytoskeleton organization; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of immune response. Located in centrosome; nucleus; and spindle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SAC3D1 (SAC3 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 50.3), adrenal adult (RPKM 46.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sac3d1 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6166025..6168689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6116004..6118586, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 550 Neighboring gene N-acetylated alpha-linked acidic dipeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene sorting nexin 15 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene ADP-ribosylation factor-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in cytoplasm  
    located_in microtubule cytoskeleton PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in spindle  
    located_in spindle PubMed 

    General protein information

    Preferred Names
    SAC3 domain-containing protein 1
    Names
    SAC3 homology domain-containing protein 1
    Sac3 homology domain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133678.3NP_598439.3  SAC3 domain-containing protein 1

      See identical proteins and their annotated locations for NP_598439.3

      Status: VALIDATED

      Source sequence(s)
      AK075930, BI134670
      Consensus CDS
      CCDS37896.1
      UniProtKB/Swiss-Prot
      A6H687, B7ZMU9, Q8BVY1, Q9QXE1
      UniProtKB/TrEMBL
      G5E8Q7
      Related
      ENSMUSP00000109161.2, ENSMUST00000113533.3
      Conserved Domains (1) summary
      pfam03399
      Location:150356
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6166025..6168689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161651.1XP_036017544.1  SAC3 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cl24019
      Location:81266
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
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