Kifc3 kinesin family member C3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kifc3provided by MGI
Official Full Name: kinesin family member C3provided by MGI
Primary source: MGI:MGI:109202
See related: Ensembl:ENSMUSG00000031788 AllianceGenome:MGI:109202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity and microtubule binding activity. Acts upstream of or within Golgi organization and microtubule-based process. Located in Golgi apparatus. Part of kinesin complex. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and respiratory system. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 47.2), lung adult (RPKM 23.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 47.12 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95826456..95929454, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95099828..95202826, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway.
Title: KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway.
Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.
Title: Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.
The study connects defects in intracellular trafficking with insufficient autophagy in old organisms and identifies Kifc3 as a novel target for future interventions aiming at correcting autophagic activity with anti-aging purposes.
Title: Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.
KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes.
Title: Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells.
KIFC3 plays a complementary role in Golgi positioning and integration
Title: Role of KIFC3 motor protein in Golgi positioning and integration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325457 (e-PCR)
- UniSTS:159795

PMC86668P1 (e-PCR)
- UniSTS:273541

BB123200 (e-PCR)
- UniSTS:185767

Kifc3 (e-PCR), detects polymorphism
- UniSTS:525252

D8Mit349 (e-PCR), detects polymorphism
- UniSTS:131563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based process	IDA Inferred from Direct Assay more info	PubMed
involved_in zonula adherens maintenance	ISO Inferred from Sequence Orthology more info
involved_in zonula adherens maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in zonula adherens	ISO Inferred from Sequence Orthology more info
located_in zonula adherens	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIFC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145831.2 → NP_001139303.1 kinesin-like protein KIFC3 isoform b

Status: VALIDATED

Source sequence(s)

AC103935

Consensus CDS

CCDS52639.1

UniProtKB/TrEMBL

E9PWU7

Related

ENSMUSP00000126784.2, ENSMUST00000169748.9

Conserved Domains (2) summary

COG1196
Location:38 → 355

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:405 → 722

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_001145832.2 → NP_001139304.1 kinesin-like protein KIFC3 isoform c

See identical proteins and their annotated locations for NP_001139304.1

Status: VALIDATED

Source sequence(s)

AC103935

Consensus CDS

CCDS52638.1

UniProtKB/TrEMBL

A0A1D5RLM0

Related

ENSMUSP00000148425.2, ENSMUST00000213004.2

Conserved Domains (3) summary

cd01366
Location:304 → 631

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

pfam00225
Location:312 → 629

Kinesin; Kinesin motor domain

cl12013
Location:38 → 167

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001372312.1 → NP_001359241.1 kinesin-like protein KIFC3 isoform d

Status: VALIDATED

Source sequence(s)

AC102518, AC103935

Conserved Domains (2) summary

COG1196
Location:230 → 547

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:597 → 924

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_001372313.1 → NP_001359242.1 kinesin-like protein KIFC3 isoform e

Status: VALIDATED

Source sequence(s)

AC102518, AC103935

Conserved Domains (2) summary

COG1196
Location:181 → 498

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:548 → 875

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_001372314.1 → NP_001359243.1 kinesin-like protein KIFC3 isoform f

Status: VALIDATED

Source sequence(s)

AC103935

Conserved Domains (2) summary

COG1196
Location:181 → 498

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:548 → 875

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_001372315.1 → NP_001359244.1 kinesin-like protein KIFC3 isoform g

Status: VALIDATED

Source sequence(s)

AC103935

Conserved Domains (2) summary

TIGR02168
Location:111 → 438

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:441 → 768

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_001372316.1 → NP_001359245.1 kinesin-like protein KIFC3 isoform h

Status: VALIDATED

Source sequence(s)

AC103935

Conserved Domains (3) summary

TIGR02168
Location:58 → 367

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:370 → 697

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

cl27170
Location:6 → 86

DUF460; Protein of unknown function (DUF460)
NM_001372317.1 → NP_001359246.1 kinesin-like protein KIFC3 isoform h

Status: VALIDATED

Source sequence(s)

AC103935

Conserved Domains (3) summary

TIGR02168
Location:58 → 367

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:370 → 697

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

cl27170
Location:6 → 86

DUF460; Protein of unknown function (DUF460)
NM_001414042.1 → NP_001400971.1 kinesin-like protein KIFC3 isoform i

Status: VALIDATED

Source sequence(s)

AC103935
NM_010631.3 → NP_034761.3 kinesin-like protein KIFC3 isoform a

See identical proteins and their annotated locations for NP_034761.3

Status: VALIDATED

Source sequence(s)

AC103935

Consensus CDS

CCDS52640.1

UniProtKB/Swiss-Prot

O35072, O35231, Q1WNZ8, Q3UX36, Q3V0U4, Q6NS71, Q8R3Y4, Q91YQ2, Q99KP7

Related

ENSMUSP00000034240.8, ENSMUST00000034240.15

Conserved Domains (3) summary

cd01366
Location:441 → 768

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

pfam00225
Location:449 → 766

Kinesin; Kinesin motor domain

cl12013
Location:175 → 337

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95826456..95929454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530723.4 → XP_006530786.1 kinesin-like protein KIFC3 isoform X6

Conserved Domains (2) summary

TIGR02168
Location:160 → 487

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:490 → 817

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_030243308.2 → XP_030099168.1 kinesin-like protein KIFC3 isoform X7

Conserved Domains (2) summary

TIGR02168
Location:160 → 487

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:490 → 817

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_006530718.5 → XP_006530781.1 kinesin-like protein KIFC3 isoform X1

Conserved Domains (2) summary

COG1196
Location:229 → 546

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:596 → 923

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_006530720.5 → XP_006530783.1 kinesin-like protein KIFC3 isoform X3

Conserved Domains (2) summary

COG1196
Location:230 → 547

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:597 → 924

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_030243309.2 → XP_030099169.1 kinesin-like protein KIFC3 isoform X8

Conserved Domains (2) summary

TIGR02168
Location:111 → 438

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01366
Location:441 → 768

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_006530721.4 → XP_006530784.1 kinesin-like protein KIFC3 isoform X4

See identical proteins and their annotated locations for XP_006530784.1

Conserved Domains (2) summary

COG1196
Location:181 → 498

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:548 → 875

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_036153766.1 → XP_036009659.1 kinesin-like protein KIFC3 isoform X2

Conserved Domains (2) summary

COG1196
Location:227 → 544

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:594 → 921

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_036153768.1 → XP_036009661.1 kinesin-like protein KIFC3 isoform X9

Conserved Domains (2) summary

COG1196
Location:38 → 355

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:405 → 732

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_036153769.1 → XP_036009662.1 kinesin-like protein KIFC3 isoform X9

Conserved Domains (2) summary

COG1196
Location:38 → 355

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:405 → 732

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_036153770.1 → XP_036009663.1 kinesin-like protein KIFC3 isoform X11

Conserved Domains (2) summary

COG1196
Location:35 → 305

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:304 → 631

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_006530726.5 → XP_006530789.1 kinesin-like protein KIFC3 isoform X10

Conserved Domains (2) summary

COG1196
Location:3 → 320

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:370 → 697

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
XM_006530724.5 → XP_006530787.1 kinesin-like protein KIFC3 isoform X9

See identical proteins and their annotated locations for XP_006530787.1

Conserved Domains (2) summary

COG1196
Location:38 → 355

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01366
Location:405 → 732

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins