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    Alr Augmenter of liver regeneration [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alrprovided by FlyBase
    Official Full Name
    Augmenter of liver regenerationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031068
    Locus tag
    Dmel_CG12534
    See related
    AllianceGenome:FB:FBgn0031068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alr; CG12534; dErv1; Dmel\CG12534
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity and flavin-dependent sulfhydryl oxidase activity. Involved in tissue regeneration. Predicted to be active in mitochondrion. Is expressed in adult head; ectoderm; organism; and prothoracic leg disc. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alr in Genome Data Viewer
    Location:
    18F1-18F1; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19748314..19750167)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19642347..19644200)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45501 Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene parvin Neighboring gene ATP binding cassette subfamily D member 3 Neighboring gene uncharacterized protein Neighboring gene zelda

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles. Murari A, et al. STAR Protoc, 2021 Dec 17. PMID 34977670, Free PMC Article
    2. Three genes control the timing, the site and the size of blastema formation in Drosophila. McClure KD, et al. Dev Biol, 2008 Jul 1. PMID 18485344, Free PMC Article
    3. An antibody toolbox to track complex I assembly defines AIF's mitochondrial function. Murari A, et al. J Cell Biol, 2020 Oct 5. PMID 32936885, Free PMC Article
    4. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Weake VM, et al. EMBO J, 2008 Jan 23. PMID 18188155, Free PMC Article
    5. A protein network-guided screen for cell cycle regulators in Drosophila. Guest ST, et al. BMC Syst Biol, 2011 May 6. PMID 21548953, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial disulfide relay system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    augmenter of liver regeneration
    Names
    Alr-PA
    Alr-PB
    CG12534-PA
    CG12534-PB
    NP_001259731.1
    NP_608353.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19748314..19750167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272802.2 → NP_001259731.1  augmenter of liver regeneration, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PVB3
      Conserved Domains (1) summary
      pfam04777
      Location:166 → 257
      Evr1_Alr; Erv1 / Alr family

    2. NM_134509.4 → NP_608353.2  augmenter of liver regeneration, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608353.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUU5
      Conserved Domains (1) summary
      cl02107
      Location:104 → 255
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0PVB3 C0PVB3
    Q7KUU5 Q7KUU5
    Q8SX43 Q8SX43

    Gene LinkOut

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