Zwilch zwilch [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zwilchprovided by FlyBase
Official Full Name: zwilchprovided by FlyBase
Primary source: FLYBASE:FBgn0061476
Locus tag: Dmel_CG18729
See related: AllianceGenome:FB:FBgn0061476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18639; CG18729; Dmel\CG18729; zwilch
Summary: Involved in mitotic spindle assembly checkpoint signaling. Located in cytoplasm; kinetochore; and spindle. Part of RZZ complex. Is expressed in spermatozoon. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31210966..31213376, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27036688..27039098, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	IDA Inferred from Direct Assay more info	PubMed
part_of RZZ complex	IEA Inferred from Electronic Annotation more info
part_of RZZ complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain