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    Tbcc Tubulin-binding cofactor C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 319048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbccprovided by FlyBase
    Official Full Name
    Tubulin-binding cofactor Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051961
    Locus tag
    Dmel_CG31961
    See related
    AllianceGenome:FB:FBgn0051961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD34582; CG31961; CG3381; Dmel\CG31961; TBCC
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human TBCC (tubulin folding cofactor C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tbcc in Genome Data Viewer
    Location:
    24D8-24D8; 2-11 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4186250..4187793, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4186250..4187793, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Odorant receptor 24a Neighboring gene long non-coding RNA:CR45791 Neighboring gene long non-coding RNA:CR44057 Neighboring gene lectin-24Db Neighboring gene Nicotinate phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity. Jang YG, et al. Mol Cells, 2020 Aug 31. PMID 32759469, Free PMC Article
    2. Arl2- and Msps-dependent microtubule growth governs asymmetric division. Chen K, et al. J Cell Biol, 2016 Mar 14. PMID 26953351, Free PMC Article
    3. A conceptual view at microtubule plus end dynamics in neuronal axons. Voelzmann A, et al. Brain Res Bull, 2016 Sep. PMID 27530065, Free PMC Article
    4. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article
    5. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin-binding cofactor C
    Names
    CG31961-PA
    CG31961-PB
    Tbcc-PA
    Tbcc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4186250..4187793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164570.2 → NP_722959.1  Tubulin-binding cofactor C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP0
      Related
      FBpp0077173
      Conserved Domains (2) summary
      pfam07986
      Location:188 → 306
      TBCC; Tubulin binding cofactor C
      pfam16752
      Location:16 → 128
      TBCC_N; Tubulin-specific chaperone C N-terminal domain

    2. NM_164571.2 → NP_722960.1  Tubulin-binding cofactor C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TP0
      Related
      FBpp0077174
      Conserved Domains (2) summary
      pfam07986
      Location:188 → 306
      TBCC; Tubulin binding cofactor C
      pfam16752
      Location:16 → 128
      TBCC_N; Tubulin-specific chaperone C N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TP0 Q95TP0

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