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    Fpgs1 Folylpolyglutamate synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32212, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fpgs1provided by FlyBase
    Official Full Name
    Folylpolyglutamate synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030407
    Locus tag
    Dmel_CG2543
    See related
    AllianceGenome:FB:FBgn0030407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2543; Dmel\CG2543; Fpgs
    Summary
    Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to be active in cytosol and mitochondrial matrix. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fpgs1 in Genome Data Viewer
    Location:
    11B3-11B4; 1-39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12611867..12615530)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12505900..12509563)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Secretory 16 Neighboring gene antisense RNA:CR45621 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44568

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Baker BM, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074789, Free PMC Article
    2. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    3. A P-insertion screen identifying novel X-linked essential genes in Drosophila. Bourbon HM, et al. Mech Dev, 2002 Jan. PMID 11744370
    4. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    5. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Dimova DK, et al. Genes Dev, 2003 Sep 15. PMID 12975318, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    folylpolyglutamate synthase 1
    Names
    CG2543-PA
    CG2543-PB
    Fpgs1-PA
    Fpgs1-PB
    folylpolyglutamate synthase
    NP_001285161.1
    NP_572814.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12611867..12615530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132586.2 → NP_572814.1  folylpolyglutamate synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRU3, Q9VYL1
      Related
      FBpp0073488
      Conserved Domains (1) summary
      PLN02881
      Location:90 → 554
      PLN02881; tetrahydrofolylpolyglutamate synthase

    2. NM_001298232.1 → NP_001285161.1  folylpolyglutamate synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRU3, X2JDF2
      Conserved Domains (1) summary
      PLN02881
      Location:60 → 524
      PLN02881; tetrahydrofolylpolyglutamate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRU3 Q8MRU3
    Q9VYL1 Q9VYL1
    X2JDF2 X2JDF2

    Gene LinkOut

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