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    Patsas patsas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Patsasprovided by FlyBase
    Official Full Name
    patsasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029137
    Locus tag
    Dmel_CG6618
    See related
    AllianceGenome:FB:FBgn0029137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6618; Dmel\CG6618
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in Golgi apparatus. Is expressed in adult brain; adult central nervous system; larval brain; and larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Patsas in Genome Data Viewer
    Location:
    33C4-33C4; 2-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12100765..12103285, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12100765..12103285, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Peroxin 19 Neighboring gene uncharacterized protein Neighboring gene Methyltransferase 2 Neighboring gene Ced-12 Neighboring gene Threonyl-tRNA synthetase Neighboring gene Rab6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The developmental role of warthog, the notch modifier encoding Drab6. Purcell K, et al. J Cell Biol, 1999 Aug 23. PMID 10459009, Free PMC Article
    2. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
    3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
    4. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
    5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    patsas
    Names
    CG6618-PA
    CG6618-PC
    CG6618-PD
    Patsas-PA
    Patsas-PC
    Patsas-PD
    NP_001356894.1
    NP_001356957.1
    • non-AUG (AAG) translation initiation
    NP_723724.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12100765..12103285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370040.1 → NP_001356957.1  patsas, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K4L3
      Conserved Domains (4) summary
      COG0666
      Location:113 → 306
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:187 → 214
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:283 → 336
      Ank_4; Ankyrin repeats (many copies)
      pfam01529
      Location:455 → 567
      DHHC; DHHC palmitoyltransferase

    2. NM_001370041.1 → NP_001356894.1  patsas, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A499GVI2
      Conserved Domains (4) summary
      COG0666
      Location:85 → 278
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:159 → 186
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:255 → 308
      Ank_4; Ankyrin repeats (many copies)
      pfam01529
      Location:427 → 539
      DHHC; DHHC palmitoyltransferase

    3. NM_164993.2 → NP_723724.1  patsas, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKB1
      Related
      FBpp0079944
      Conserved Domains (5) summary
      cd00204
      Location:159 → 274
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:425 → 539
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:160 → 252
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:255 → 308
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:159 → 186
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A499GVI2 A0A499GVI2
    A0A4D6K4L3 A0A4D6K4L3
    Q9U722 Q9U722
    Q9VKB1 Q9VKB1

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