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    tHMG2 testis-enriched HMG-box-containing protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42651, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tHMG2provided by FlyBase
    Official Full Name
    testis-enriched HMG-box-containing protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038979
    Locus tag
    Dmel_CG7046
    See related
    AllianceGenome:FB:FBgn0038979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT28425; CG7046; Dmel\CG7046; thmg-2; tHMG-2
    Summary
    Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm; nucleus; and polytene chromosome interband. Is expressed in spermatid; spermatocyte; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tHMG2 in Genome Data Viewer
    Location:
    94B1-94B1; 3-75 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22492953..22493746)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18318675..18319468)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Chaperonin containing TCP1 subunit 1 Neighboring gene testis-enriched HMG-box-containing protein 1 Neighboring gene Octopamine beta1 receptor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933
    2. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
    3. High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. Ragab A, et al. Genetics, 2006 Feb. PMID 16299391, Free PMC Article
    4. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
    5. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-enriched HMG-box-containing protein 2
    Names
    CG7046-PA
    CG7046-PB
    tHMG2-PA
    tHMG2-PB
    testis-enriched HMG-box-containing protein-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22492953..22493746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170218.2 → NP_001163689.1  testis-enriched HMG-box-containing protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIT5, Q8T957
      Conserved Domains (1) summary
      cd01390
      Location:9 → 75
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

    2. NM_142799.2 → NP_651056.1  testis-enriched HMG-box-containing protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T957, Q9VCZ4
      Related
      FBpp0083652
      Conserved Domains (1) summary
      cd01390
      Location:8 → 74
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIT5 E1JIT5
    Q8T957 Q8T957
    Q9VCZ4 Q9VCZ4

    Gene LinkOut

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