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    CG46339 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44359, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG46339provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285963
    Locus tag
    Dmel_CG46339
    See related
    AllianceGenome:FB:FBgn0285963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07466; CG5518; Dmel\CG46339; sda; slamdance
    Summary
    Enables aminopeptidase activity. Involved in several processes, including cell dedifferentiation; germ-line stem-cell niche homeostasis; and male germ-line stem cell population maintenance. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG46339 in Genome Data Viewer
    Location:
    97D7-97D9; 3-92 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26915761..26945309)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22741483..22771031)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rough Neighboring gene Transcript 48 Neighboring gene Ets at 97D Neighboring gene transfer RNA:Glutamine-TTG 1-2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila. Kumimoto EL, et al. G3 (Bethesda), 2013 Apr 9. PMID 23550139, Free PMC Article
    2. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Lim C, et al. Cell Rep, 2015 Oct 13. PMID 26440886, Free PMC Article
    3. Seizure-suppressor genes: can they help spearhead the discovery of novel therapeutic targets for epilepsy? Silva-Cardoso GK, et al. Expert Opin Ther Targets, 2023 Jul-Dec. PMID 37589085, Free PMC Article
    4. Cellular mechanisms underlying adult tissue plasticity in Drosophila. Nagai H, et al. Fly (Austin), 2022 Dec. PMID 35470772, Free PMC Article
    5. Genetic screen for genes involved in Chk2 signaling in Drosophila. Park SY, et al. Mol Cells, 2008 Oct 31. PMID 18612247

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sda promotes spermatogonial dedifferentiation during aging and regeneration. Sda is required for accumulation of mature DE-cadherin.
      Title: An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell dedifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG46339-PA
    CG46339-PB
    CG46339-PC
    CG46339-PD
    CG46339-PE
    CG46339-PF
    slamdance
    NP_001097939.1
    NP_001247323.1
    NP_001263001.1
    NP_001350863.1
    NP_001350864.1
    NP_652744.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26915761..26945309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276072.1 → NP_001263001.1  uncharacterized protein Dmel_CG46339, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH77
      Conserved Domains (3) summary
      cd09601
      Location:297 → 769
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:296 → 698
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:846 → 1138
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_001260394.2 → NP_001247323.1  uncharacterized protein Dmel_CG46339, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7L8
      Conserved Domains (3) summary
      cd09601
      Location:186 → 658
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:185 → 587
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:735 → 1027
      ERAP1_C; ERAP1-like C-terminal domain

    3. NM_001104469.3 → NP_001097939.1  uncharacterized protein Dmel_CG46339, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRD7
      Conserved Domains (2) summary
      cd09601
      Location:285 → 757
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam11838
      Location:834 → 1114
      ERAP1_C; ERAP1-like C-terminal domain

    4. NM_144487.3 → NP_652744.2  uncharacterized protein Dmel_CG46339, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652744.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T6B0, Q9VBA3, Q9Y131
      Related
      FBpp0422658
      Conserved Domains (2) summary
      cd09601
      Location:174 → 646
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam11838
      Location:723 → 1003
      ERAP1_C; ERAP1-like C-terminal domain

    5. NM_001363936.1 → NP_001350864.1  uncharacterized protein Dmel_CG46339, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRD7
      Conserved Domains (2) summary
      cd09601
      Location:285 → 757
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam11838
      Location:834 → 1114
      ERAP1_C; ERAP1-like C-terminal domain

    6. NM_001363935.1 → NP_001350863.1  uncharacterized protein Dmel_CG46339, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T6B0, Q9VBA3, Q9Y131
      Conserved Domains (2) summary
      cd09601
      Location:174 → 646
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam11838
      Location:723 → 1003
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7L8 A0A0B4K7L8
    A0A0B4KH77 A0A0B4KH77
    A8JRD7 A8JRD7
    Q9VBA3 Q9VBA3

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