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    Nost Nostrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8673992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nostprovided by FlyBase
    Official Full Name
    Nostrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259734
    Locus tag
    Dmel_CG42388
    See related
    AllianceGenome:FB:FBgn0259734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15364; CG33224; CG4040; CG42388; Dmel\CG42388; nost; NOSTRIN
    Old locus tag
    CG4040; Dmel_CG15364; Dmel_CG33224; Dmel_CG4040
    Summary
    Enables lipid binding activity. Involved in epithelial cell differentiation; plasma membrane tubulation; and regulation of adherens junction organization. Located in endosome. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; germline cell; and gut section. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nost in Genome Data Viewer
    Location:
    8C3-8C4; 1-26 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9030205..9054575)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8924238..8948608)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene retinal degeneration A Neighboring gene long non-coding RNA:CR43836 Neighboring gene uncharacterized protein Neighboring gene mir-31b stem loop Neighboring gene antisense RNA:CR45538 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects. Schultheis D, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733382, Free PMC Article
    2. Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis. Zobel T, et al. J Cell Sci, 2015 Feb 1. PMID 25413347
    3. Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis. Takeda T, et al. Open Biol, 2013 Aug 7. PMID 23926047, Free PMC Article
    4. Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin. Brüser L, et al. Cold Spring Harb Perspect Biol, 2017 Mar 1. PMID 28096264, Free PMC Article
    5. Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis. Biton T, et al. J Cell Biol, 2023 Nov 6. PMID 37707500, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germarium-derived female germ-line cyst encapsulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plasma membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of adherens junction organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nostrin
    Names
    CG42388-PC
    CG42388-PD
    CG42388-PE
    CG42388-PF
    CG42388-PG
    CG42388-PH
    Nost-PC
    Nost-PD
    Nost-PE
    Nost-PF
    Nost-PG
    Nost-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9030205..9054575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298100.1 → NP_001285029.1  nostrin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAX8
      Conserved Domains (2) summary
      cd07658
      Location:663 → 908
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:1276 → 1328
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

    2. NM_001201637.1 → NP_001188566.1  nostrin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP19, H1UUM2
      Conserved Domains (2) summary
      cd07658
      Location:103 → 346
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:714 → 766
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

    3. NM_132287.3 → NP_572515.2  nostrin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572515.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MQH0, Q7K115
      Conserved Domains (2) summary
      cd07658
      Location:9 → 253
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:621 → 673
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

    4. NM_001169241.1 → NP_001162712.1  nostrin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR1, Q7K115
      Conserved Domains (2) summary
      cd07658
      Location:6 → 249
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:617 → 669
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

    5. NM_001201638.2 → NP_001188567.1  nostrin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJS0
      Conserved Domains (2) summary
      cd07658
      Location:558 → 803
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:1171 → 1223
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

    6. NM_001169240.2 → NP_001162711.1  nostrin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJS0
      Conserved Domains (2) summary
      cd07658
      Location:558 → 803
      F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
      cd11823
      Location:1171 → 1223
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RJS0 B5RJS0
    D5SHR1 D5SHR1
    H1UUM2 H1UUM2
    M9MQH0 M9MQH0
    Q7K115 Q7K115
    X2JAX8 X2JAX8

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