Nrx-1 Neurexin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nrx-1provided by FlyBase
Official Full Name: Neurexin 1provided by FlyBase
Primary source: FLYBASE:FBgn0038975
Locus tag: Dmel_CG7050
See related: AllianceGenome:FB:FBgn0038975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7050; CT21808; Dmel\CG7050; dnrx; dNrx; Dnrx; DNrx; dnrx-1; dnrx1; dNRXN3; neurexin; nrx; Nrx; nrx-1; Nrx-I; nrx1; Nrx1
Summary: Enables apolipoprotein binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including neuromuscular synaptic transmission; positive regulation of synaptic vesicle endocytosis; and synapse organization. Located in neuromuscular junction; presynaptic membrane; and type I terminal bouton. Part of trans-synaptic protein complex. Is expressed in several structures, including NMJ bouton; adult head; adult mushroom body; brain; and synaptic neuropil domain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2; alcohol dependence; and nicotine dependence. Orthologous to several human genes including NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94A16-94B1; 3-75 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22468512..22486969)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18294234..18312691)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo.
Title: Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo.
Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila.
Title: Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila.
Nrx functions with components of the BMP signaling pathway to ensure proper microtubule organization and axonal transport which is crucial for proper neuronal function.
Title: Coordinated Regulation of Axonal Microtubule Organization and Transport by Drosophila Neurexin and BMP Pathway.
The authors find that axonal branch growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin. These adhesion complexes provide stability for filopodia by a 'stick-and-grow' based mechanism wholly independent of synaptic activity.
Title: Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity.
The disruption of DNlg1, DNlg2, or their presynaptic partner neurexin (DNrx) led to a dramatic decrease in the amount of F-actin. Further study showed that DNlg1, but not DNlg2 or DNlg3, directly interacts with the WRC via its C-terminal interacting receptor sequence.
Title: Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction.
findings reveal that neurexin regulates nighttime sleep by mediating the synaptic transmission of alphabeta neurons. This study elucidates the role of synaptic transmission in sleep regulation, and might offer insights into the mechanism of sleep disturbances in patients with autism disorders.
Title: Neurexin regulates nighttime sleep by modulating synaptic transmission.
DNrx mutants have reduced levels of Wit. Dnrx is required for proper localization and stability of Wit.
Title: Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions.
Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1)
Title: The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering.
DNRX was expressed preferentially in central and motor neurons in embryos, larvae and adults, but not in glial cells. DNRX was expressed in pre- and post-synaptic areas in third instar larvae neuromuscular junctions.
Title: Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporter.
Dnrx1 affects synaptic plasticity and sleep.
Title: Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuroligin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin A transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
part_of trans-synaptic protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in type I terminal bouton	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: neurexin 1

Names: CG7050-PA; CG7050-PB; CG7050-PC; CG7050-PD; CG7050-PE; CG7050-PF; CG7050-PG; CG7050-PH; CG7050-PI; Neurexin-1; Neurexin-like; Nrx-1-PA; Nrx-1-PB; Nrx-1-PC; Nrx-1-PD; Nrx-1-PE; Nrx-1-PF; Nrx-1-PG; Nrx-1-PH; Nrx-1-PI; drosophila neurexin; neurexin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22468512..22486969

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079725.5 → NP_524449.1 neurexin 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524449.1

Status: REVIEWED

UniProtKB/TrEMBL

A5HBQ4, Q9VCZ9

Related

FBpp0083649

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001170216.3 → NP_001163687.1 neurexin 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3KN41

UniProtKB/TrEMBL

A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275912.2 → NP_001262841.1 neurexin 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262841.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH61, A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001300538.1 → NP_001287467.1 neurexin 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287467.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3KN41

UniProtKB/TrEMBL

A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275913.2 → NP_001262842.1 neurexin 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262842.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3KN41

UniProtKB/TrEMBL

A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275911.2 → NP_001262840.1 neurexin 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262840.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGL0, A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275909.2 → NP_001262838.1 neurexin 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262838.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3KN41

UniProtKB/TrEMBL

A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275910.2 → NP_001262839.1 neurexin 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262839.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGQ3, A5HBQ4

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain
NM_001275908.2 → NP_001262837.1 neurexin 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262837.1

Status: REVIEWED

UniProtKB/TrEMBL

A5HBQ4, Q9VCZ9

Conserved Domains (4) summary

cd00054
Location:311 → 347

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:110 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:746 → 777

EGF; EGF-like domain

pfam02210
Location:386 → 517

Laminin_G_2; Laminin G domain