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    Hsp70Ab Heat shock protein 70 Ab [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44920, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Hsp70Abprovided by FlyBase
    Official Full Name
    Heat shock protein 70 Abprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013276
    Locus tag
    Dmel_CG18743
    See related
    AllianceGenome:FB:FBgn0013276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87A7 hsp70; CG18743; dhsp70; dHsp70; Dm-hsp70; Dmel\CG18743; DMHSP7A2; GRP78; hs70; hsp 70; Hsp 70; hsp-70; Hsp-70; hsp70; Hsp70; HSP70; hsp70 87A; hsp70(87A); Hsp70-Ab; hsp70a; hsp70A; Hsp70A; hsp70Ab; Hsp70ab; Hsp70aB; HSP70Ab; Hsp70b; HSP70cA2
    Summary
    Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in heat shock-mediated polytene chromosome puffing and response to hypoxia. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsp70Ab in Genome Data Viewer
    Location:
    87A3-87A3; 3-51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11958535..11960909)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7784257..7786631)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 Aa Neighboring gene uncharacterized protein Neighboring gene aurora A Neighboring gene uncharacterized protein Neighboring gene Glutamate Carrier 1 Neighboring gene Transport and Golgi organization 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. Zehring WA, et al. J Biol Chem, 1990 May 25. PMID 2187861
    2. The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains. Udvardy A, et al. J Mol Biol, 1985 Sep 20. PMID 2997449
    3. Expression of Heat Shock Protein 70 Is Insufficient To Extend Drosophila melanogaster Longevity. Xiao C, et al. G3 (Bethesda), 2019 Dec 3. PMID 31624139, Free PMC Article
    4. Hyperthermic preconditioning of presynaptic calcium regulation in Drosophila. Klose MK, et al. J Neurophysiol, 2008 May. PMID 18272873
    5. Targeting HSP70 to motoneurons protects locomotor activity from hyperthermia in Drosophila. Xiao C, et al. Dev Neurobiol, 2007 Mar. PMID 17443800

    See all (523) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic animals) suggest that dual enzymatic activity of Fic is, in part, regulated by Fic dimerization, as loss of this dimerization increases AMPylation and reduces deAMPylation of BiP/Grp78. (Fic = Fic domain-containing protein; BiP/Grp78 = molecular chaperone BiP)
      Title: Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.
    2. All insertions reduced Hsp70A expression below that of a control strain, the magnitude of the reduction was inversely related to the number of nucleotides between the transcription start site and the insertion site.
      Title: Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heat shock-mediated polytene chromosome puffing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 70 Ab
    Names
    70 kDa heat shock protein, cytosolic A 2
    87A locus
    CG18743-PA
    Heat-shock-protein-70Ab
    Hsp70Ab-PA
    heat shock 70
    heat shock protein 70
    heat shock protein 70Ab
    heat-shock protein 70
    protein 70

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11958535..11960909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080059.3 → NP_524798.2  heat shock protein 70 Ab [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524798.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02825, P82910, Q5BI85, Q8MT04, Q95NG7, Q9BIS5
      UniProtKB/TrEMBL
      F3YDI6
      Related
      FBpp0081956
      Conserved Domains (2) summary
      cd10233
      Location:3 → 379
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:2 → 642
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02825.3 P02825
    P82910.2

    Gene LinkOut

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