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    Claspin claspin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Claspinprovided by FlyBase
    Official Full Name
    claspinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052251
    Locus tag
    Dmel_CG32251
    See related
    AllianceGenome:FB:FBgn0052251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1326; CG32251; claspin; Dmel\CG32251
    Summary
    Predicted to enable anaphase-promoting complex binding activity. Involved in mitotic DNA replication checkpoint signaling. Located in nucleus. Is expressed in eye disc; organism; and ovary. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Claspin in Genome Data Viewer
    Location:
    64B1-64B1; 3-12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4313483..4318608)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4313483..4318608)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ferredoxin 2 Neighboring gene dusky-like Neighboring gene Peroxisomal Membrane Protein 34 Neighboring gene uncharacterized protein Neighboring gene Cdc42-interacting protein 4 Neighboring gene long non-coding RNA:CR45156

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation. Choi SH, et al. Dev Dyn, 2017 Jun. PMID 28294450, Free PMC Article
    2. Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts. Kizhedathu A, et al. Elife, 2021 Oct 8. PMID 34622778, Free PMC Article
    3. Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. Lee EM, et al. DNA Repair (Amst), 2012 Sep 1. PMID 22796626
    4. Nuclear lamina dysfunction triggers a germline stem cell checkpoint. Barton LJ, et al. Nat Commun, 2018 Sep 27. PMID 30262885, Free PMC Article
    5. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Meng Z, et al. Mol Biol Cell, 2011 Aug 15. PMID 21680713, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Claspin plays a major role in the initiation and elongation stages of chorion gene amplification by localizing to the amplification foci in a mei-41-independent manner.
      Title: Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    claspin
    Names
    CG32251-PA
    CG32251-PB
    Claspin-PA
    Claspin-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4313483..4318608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300005.1 → NP_001286934.1  claspin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRB5, Q8MYR6, X2JAN5
      Conserved Domains (3) summary
      CHL00189
      Location:58 → 180
      infB; translation initiation factor 2; Provisional
      COG5271
      Location:861 → 947
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      TIGR00927
      Location:96 → 411
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. NM_168080.2 → NP_728981.1  claspin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRB5, Q8MYR6, X2JAN5
      Related
      FBpp0073142
      Conserved Domains (3) summary
      CHL00189
      Location:58 → 180
      infB; translation initiation factor 2; Provisional
      COG5271
      Location:861 → 947
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      TIGR00927
      Location:96 → 411
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRB5.1 Q8IRB5

    Gene LinkOut

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