U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cGlr2 cGAS-like receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246606, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cGlr2provided by FlyBase
    Official Full Name
    cGAS-like receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0050424
    Locus tag
    Dmel_CG30424
    See related
    AllianceGenome:FB:FBgn0050424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30424; cGLR2; Dmel\CG30424; mdcds_18556
    Summary
    Enables 2',3'-cyclic GMP-AMP synthase activity; 3',2'-cyclic GMP-AMP synthase activity; and double-stranded RNA binding activity. Involved in cGAS/STING signaling pathway; immune response involved in response to exogenous dsRNA; and response to virus. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cGlr2 in Genome Data Viewer
    Location:
    60E11-60E11; 2-107 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24965275..24967298, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20852798..20854821, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44830 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L19 Neighboring gene uncharacterized protein Neighboring gene Pherokine 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila. Cai H, et al. Immunity, 2023 Sep 12. PMID 37659413
    2. Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage. Moehlman AT, et al. PLoS Genet, 2023 Jul. PMID 37440574, Free PMC Article
    3. cGAS-like receptor-mediated immunity: the insect perspective. Cai H, et al. Curr Opin Immunol, 2022 Feb. PMID 35149240
    4. Two cGAS-like receptors induce antiviral immunity in Drosophila. Holleufer A, et al. Nature, 2021 Sep. PMID 34261128
    5. Molecular and genetic organization of Drosophila melanogaster polytene chromosomes: evidence for two types of interband regions. Demakov S, et al. Genetica, 2004 Nov. PMID 15609554

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two cGAS-like receptors induce antiviral immunity in Drosophila.
      Title: Two cGAS-like receptors induce antiviral immunity in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2',3'-cyclic GMP-AMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',2'-cyclic GMP-AMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGAS/STING signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGAS/STING signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response involved in response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cGAS-like receptor 2
    Names
    CG30424-PB
    CG30424-PC
    CG30424-PD
    CG30424-PE
    CG30424-PF
    cGlr2-PB
    cGlr2-PC
    cGlr2-PD
    cGlr2-PE
    cGlr2-PF
    NP_001097453.1
    NP_001097454.1
    NP_001097455.1
    NP_001286867.1
    NP_001400984.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24965275..24967298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103983.2 → NP_001097453.1  cGAS-like receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIH6
      Conserved Domains (1) summary
      pfam03281
      Location:21 → 76
      Mab-21; Mab-21 protein

    2. NM_001299938.1 → NP_001286867.1  cGAS-like receptor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGP4
      Conserved Domains (1) summary
      pfam03281
      Location:23 → 88
      Mab-21; Mab-21 protein

    3. NM_001414074.1 → NP_001400984.1  cGAS-like receptor 2, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LGP4, A8DYP7, A8DYP8, Q5BIH6

    4. NM_001103985.2 → NP_001097455.1  cGAS-like receptor 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LGP4, A8DYP7, A8DYP8, Q5BIH6
      Conserved Domains (1) summary
      pfam03281
      Location:1 → 289
      Mab-21; Mab-21 protein

    5. NM_001103984.2 → NP_001097454.1  cGAS-like receptor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYP8
      Conserved Domains (1) summary
      pfam03281
      Location:1 → 42
      Mab-21; Mab-21 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYP7.2 A8DYP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools