Prx2 Peroxiredoxin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prx2provided by FlyBase
Official Full Name: Peroxiredoxin 2provided by FlyBase
Primary source: FLYBASE:FBgn0040309
Locus tag: Dmel_CG1633
See related: AllianceGenome:FB:FBgn0040309
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPRDX2; dPrx I; dPrx1; dPrx2; Dpx-4783; DPx-4783; DPx4783; Jafrac; JAFRAC 1; jafrac1; Jafrac1; jf1; PRDX1; PRDX1/2/4; PRDX1_DROME; Prx; Prx4783; SSP5111; T20; TPX-1
Summary: Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cell redox homeostasis; determination of adult lifespan; and hydrogen peroxide catabolic process. Located in cytosol. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic foregut; germline cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to several human genes including PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11E11-11E11; 1-42 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13329824..13331994)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13223857..13226027)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo.
Title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion.
Activation of JNK/FOXO signaling in neurons increased the Jafrac1 expression level under both normal and oxidative stressed conditions.
Title: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
gene for thioredoxin peroxidase (DmTPx-1) was cloned and expressed, and the protein characterized
Title: Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-dependent peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxiredoxin 2

Names: CG1633-PA; CG1633-PB; CG1633-PC; CG1633-PD; CG1633-PE; Jafrac-1; Prx2-PA; Prx2-PB; Prx2-PC; Prx2-PD; Prx2-PE; jafrac1; peroxidase; peroxiredoxin; peroxiredoxin 1; peroxiredoxin 4783; peroxiredoxin I; thioredoxin peroxidase; thioredoxin peroxidase 1

NP_001285202.1

EC 1.-.-.-

EC 1.11.1.24

NP_001285203.1

EC 1.-.-.-

EC 1.11.1.24

NP_001285204.1

EC 1.-.-.-

EC 1.11.1.24

NP_477510.1

EC 1.-.-.-

EC 1.11.1.24

NP_727689.1

EC 1.-.-.-

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13329824..13331994

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298274.1 → NP_001285203.1 peroxiredoxin 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285203.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHT0, Q9V3P0

UniProtKB/TrEMBL

F6J6B9, X2JF59

Conserved Domains (1) summary

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_167359.2 → NP_727689.1 peroxiredoxin 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727689.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHT0, Q9V3P0

UniProtKB/TrEMBL

F6J6B9, X2JF59

Related

FBpp0073594

Conserved Domains (1) summary

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_058162.3 → NP_477510.1 peroxiredoxin 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477510.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHT0, Q9V3P0

UniProtKB/TrEMBL

F6J6B9, X2JF59

Related

FBpp0073595

Conserved Domains (1) summary

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001298273.1 → NP_001285202.1 peroxiredoxin 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285202.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHT0, Q9V3P0

UniProtKB/TrEMBL

F6J6B9, X2JF59

Conserved Domains (1) summary

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001298275.1 → NP_001285204.1 peroxiredoxin 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHT0, Q9V3P0

UniProtKB/TrEMBL

F6J6B9, X2JF59

Conserved Domains (1) summary

cd03015
Location:4 → 175

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...