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    GCS2beta Glucosidase 2 beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCS2betaprovided by FlyBase
    Official Full Name
    Glucosidase 2 beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032643
    Locus tag
    Dmel_CG6453
    See related
    AllianceGenome:FB:FBgn0032643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6453; Dmel\CG6453; Q9VJD1_DROME
    Summary
    Predicted to be involved in N-glycan processing. Located in endomembrane system. Is expressed in adult head; adult heart; embryonic proventriculus; and organism. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease 1. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GCS2beta in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17481988..17484307, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17481988..17484307, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene cassowary Neighboring gene four way stop Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
    2. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
    3. Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome. Herranz R, et al. Mol Ecol, 2010 Oct. PMID 20819157
    4. Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye. Hall H, et al. Mol Cell Proteomics, 2021. PMID 34332122, Free PMC Article
    5. How Genetics Has Helped Piece Together the MAPK Signaling Pathway. Ashton-Beaucage D, et al. Methods Mol Biol, 2017. PMID 27924555

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase 2 beta subunit
    Names
    CG6453-PA
    CG6453-PB
    GCS2beta-PA
    GCS2beta-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17481988..17484307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136000.3 → NP_609844.1  glucosidase 2 beta subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJD1
      Related
      FBpp0080551
      Conserved Domains (3) summary
      pfam12999
      Location:26 → 193
      PRKCSH-like; Glucosidase II beta subunit-like
      cd00112
      Location:85 → 120
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl06793
      Location:398 → 547
      PRKCSH; Glucosidase II beta subunit-like protein

    2. NM_001259134.2 → NP_001246063.1  glucosidase 2 beta subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJD1
      Conserved Domains (3) summary
      pfam12999
      Location:26 → 193
      PRKCSH-like; Glucosidase II beta subunit-like
      cd00112
      Location:85 → 120
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl06793
      Location:398 → 547
      PRKCSH; Glucosidase II beta subunit-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJD1 Q9VJD1

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