emp epithelial membrane protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: empprovided by FlyBase
Official Full Name: epithelial membrane proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0010435
Locus tag: Dmel_CG2727
See related: AllianceGenome:FB:FBgn0010435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2727; Dmel\CG2727; Emp
Summary: Predicted to enable scavenger receptor activity. Involved in protein localization to endosome and regulation of tube length, open tracheal system. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; epidermis; gut section; imaginal disc; and tracheal system. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24976456..24986070, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20863979..20873593, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways.
Title: Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in phagocytosis, recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recognition of apoptotic cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed