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    chb chromosome bows [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chbprovided by FlyBase
    Official Full Name
    chromosome bowsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021760
    Locus tag
    Dmel_CG32435
    See related
    AllianceGenome:FB:FBgn0021760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0686/07; anon-WO0104295; BcDNA:LD31673; CG32435; Chb; chb(v40); chb/mast/orbit; clasp; CLASP; dCLASP; DMAP160; Dmel\CG32435; mast; Mast; MAST; mast/orbit; Mast/Orbit; MAST/Orbit; MESR7; NEST:bs13a06; NEST:bs17d05; NEST:bs28g05; orb; orbit; Orbit; orbit/mast; orbit/MAST; Orbit/Mast; Orbit/MAST; v40
    Summary
    Enables GTP binding activity and microtubule binding activity. Involved in several processes, including germ cell development; hemocyte migration; and microtubule cytoskeleton organization. Located in several cellular components, including fusome; microtubule cytoskeleton; and spectrosome. Part of microtubule associated complex. Is expressed in several structures, including adult head; larval brain; motor neurons; ovary; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See chb in Genome Data Viewer
    Location:
    78C1-78C2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21172853..21183278)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21165953..21176378)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase 78C Neighboring gene Asparagine synthetase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state. Sousa A, et al. Cell Motil Cytoskeleton, 2007 Aug. PMID 17487886
    2. The structure of the TOG-like domain of Drosophila melanogaster Mast/Orbit. De la Mora-Rey T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Jul. PMID 23832196, Free PMC Article
    3. [Mutation chromosome bows (chb-v40), inducing the abnormal chromosome spindle in Drosophila melanogaster]. Fedorova SA, et al. Genetika, 1997 Nov. PMID 9480214
    4. [Determination of the expression phase of chb(V40) gene in the cell cycle of Drosophila melanogaster]. Trunova SA, et al. Ontogenez, 1998 Sep-Oct. PMID 9891303
    5. CLASP fluxes its mitotic muscles. Walczak CE. Nat Cell Biol, 2005 Jan. PMID 15632941

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes.
      Title: Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes.
    2. Findings suggest that Msps is a novel Rac effector that acts, in partnership with Orbit, to regionally regulate microtubule dynamics.
      Title: TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics.
    3. Orbit plays an essential role as a connector between microtubules and the contractile ring in Drosophila male meiosis.
      Title: Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis.
    4. Orbit is involved in the proper orientation of spindles towards fusomes during synchronous mitosis of spermatogonial cysts.
      Title: Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males.
    5. Data suggest a model in which CLASP and Msps converge in an antagonistic balance in the Abl signaling pathway.
      Title: Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila.
    6. Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.
      Title: Dynein and mast/orbit/CLASP have antagonistic roles in regulating kinetochore-microtubule plus-end dynamics.
    7. results suggest that Mast plays an essential role in reducing the dynamic behaviour of microtubules by specifically promoting the pause state
      Title: The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state.
    8. is an essential component for microtubule subunit incorporation into fluxing K-fibres
      Title: Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.
    9. MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.
      Title: MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.
    10. Orbit/Mast/CLASP localizes to interior rather than peripheral central spindle microtubules
      Title: Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian fusome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule plus-end IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polar microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spectrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromosome bows
    Names
    CG32435-PA
    CG32435-PB
    CG32435-PC
    MAST/Orbit
    Orbit/MAST
    Orbit/Mast/CLASP
    chb-PA
    chb-PB
    chb-PC
    clasp
    mast
    misexpression suppressor of ras 7
    multiple asters
    orbit
    orbit/clasp

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21172853..21183278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168882.2 → NP_730596.1  chromosome bows, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V279, Q9NBD7, Q9NL57
      Related
      FBpp0088469, FBtr0089460
      Conserved Domains (3) summary
      pfam12348
      Location:316 → 536
      CLASP_N; CLASP N terminal
      pfam13646
      Location:129 → 210
      HEAT_2; HEAT repeats
      sd00044
      Location:50 → 78
      HEAT; HEAT repeat [structural motif]

    2. NM_079912.4 → NP_524651.2  chromosome bows, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524651.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V279, Q9NBD7, Q9NL57
      Related
      FBpp0088470
      Conserved Domains (3) summary
      pfam12348
      Location:316 → 536
      CLASP_N; CLASP N terminal
      pfam13646
      Location:129 → 210
      HEAT_2; HEAT repeats
      sd00044
      Location:50 → 78
      HEAT; HEAT repeat [structural motif]

    3. NM_168883.1 → NP_730597.1  chromosome bows, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V279, Q9NBD7, Q9NL57
      Related
      FBpp0088471, FBtr0089462
      Conserved Domains (3) summary
      pfam12348
      Location:316 → 536
      CLASP_N; CLASP N terminal
      pfam13646
      Location:129 → 210
      HEAT_2; HEAT repeats
      sd00044
      Location:50 → 78
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NBD7.1 Q9NBD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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