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    CG4477 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4477provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035971
    Locus tag
    Dmel_CG4477
    See related
    AllianceGenome:FB:FBgn0035971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4477; SPH214
    Summary
    Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4477 in Genome Data Viewer
    Location:
    67A4-67A4; 3-28 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9250225..9251338)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9243325..9244438)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45408 Neighboring gene uncharacterized protein Neighboring gene Glutamate receptor IB Neighboring gene Peptidoglycan recognition protein LA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster. Remnant EJ, et al. Proc Natl Acad Sci U S A, 2013 Sep 3. PMID 23959864, Free PMC Article
    2. Ocnus is essential for male germ cell development in Drosophila melanogaster. Zheng Y, et al. Insect Mol Biol, 2018 Oct. PMID 29732657
    3. A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Bejarano F, et al. Genetics, 2008 Jan. PMID 18202376, Free PMC Article
    4. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article
    5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4477-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9250225..9251338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140038.1 → NP_648295.1  uncharacterized protein Dmel_CG4477 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4B1, Q9VSV4
      Related
      FBpp0076159, FBtr0076430
      Conserved Domains (2) summary
      smart00020
      Location:55 → 273
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:55 → 276
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4B1 Q8T4B1
    Q9VSV4 Q9VSV4

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