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    Gss2 Glutathione synthetase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318053, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gss2provided by FlyBase
    Official Full Name
    Glutathione synthetase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0052495
    Locus tag
    Dmel_CG32495
    See related
    AllianceGenome:FB:FBgn0052495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    32495; CG32495; Dmel\CG32495; GS; gss
    Summary
    Predicted to enable ATP binding activity and glutathione synthase activity. Involved in detoxification of arsenic-containing substance. Is expressed in adult head. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Gss2 in Genome Data Viewer
    Location:
    16F1-16F1; 1-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17899702..17906025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17793735..17800058)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glutathione synthetase 1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Ortiz JG, et al. Toxicol Sci, 2009 Feb. PMID 18779381, Free PMC Article
    2. Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster. Zhang HB, et al. PLoS Pathog, 2021 Aug. PMID 34383852, Free PMC Article
    3. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. Kilwein MD, et al. PLoS Genet, 2023 Aug. PMID 37578970, Free PMC Article
    4. Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits. Chakraborty M, et al. Nat Commun, 2019 Oct 25. PMID 31653862, Free PMC Article
    5. Embryo-larval exposure to atrazine reduces viability and alters oxidative stress parameters in Drosophila melanogaster. Figueira FH, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27687474

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detoxification of arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione synthetase 2
    Names
    CG32495-PB
    CG32495-PD
    CG32495-PE
    CG32495-PF
    CG32495-PG
    CG32495-PH
    CG32495-PI
    Gss2-PB
    Gss2-PD
    Gss2-PE
    Gss2-PF
    Gss2-PG
    Gss2-PH
    Gss2-PI
    glutathione synthetase
    NP_001162786.1
    NP_001162787.1
    NP_001285395.1
    NP_728116.1
    NP_728117.2
    NP_728118.2
    NP_788927.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17899702..17906025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176754.2 → NP_788927.2  glutathione synthetase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788927.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP33, A3FP35, Q86B44, Q8IQZ0
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    2. NM_167590.2 → NP_728117.2  glutathione synthetase 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728117.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP35, Q8IQZ1, Q8IQZ2
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    3. NM_001169316.1 → NP_001162787.1  glutathione synthetase 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX03
      Conserved Domains (1) summary
      cl00170
      Location:20 → 124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    4. NM_167591.2 → NP_728118.2  glutathione synthetase 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728118.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP33, A3FP35, Q86B44, Q8IQZ0
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 552
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    5. NM_167589.2 → NP_728116.1  glutathione synthetase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3FP35, Q8IQZ1, Q8IQZ2
      Related
      FBpp0088741
      Conserved Domains (1) summary
      pfam03917
      Location:20 → 481
      GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

    6. NM_001169315.1 → NP_001162786.1  glutathione synthetase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RL06
      Conserved Domains (1) summary
      cl00170
      Location:20 → 232
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    7. NM_001298466.1 → NP_001285395.1  glutathione synthetase 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCE7
      Conserved Domains (1) summary
      cl00170
      Location:20 → 124
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RL06 Q1RL06
    Q86B44 Q86B44
    Q8IQZ1 Q8IQZ1
    Q9VX03 Q9VX03
    X2JCE7 X2JCE7

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