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    Spn28Da Serpin 28Da [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34082, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Spn28Daprovided by FlyBase
    Official Full Name
    Serpin 28Daprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051902
    Locus tag
    Dmel_CG31902
    See related
    AllianceGenome:FB:FBgn0051902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12318; CG31902; Dmel\CG31902
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91; intermediate coronary syndrome; thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Spn28Da in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7887693..7889129, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7887693..7889129, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serpin 28Db Neighboring gene Small ribonucleoprotein particle protein SmE Neighboring gene Sno oncogene Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. Moskalev A, et al. PLoS One, 2014. PMID 24475070, Free PMC Article
    2. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    3. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    4. Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. Wong A, et al. Mol Biol Evol, 2012 Jan. PMID 21940639, Free PMC Article
    5. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c7887787-7887744 mobile_element_type = transposon:INE-1{}5672

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 28Da
    Names
    CG31902-PB
    Spn28Da-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7887693..7889129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042880.1 → NP_001036345.1  serpin 28Da [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8V6, Q4V4Z4
      Conserved Domains (1) summary
      cd00172
      Location:16 → 369
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8V6 Q0E8V6

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