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    HisT Histamine transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HisTprovided by FlyBase
    Official Full Name
    Histamine transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033196
    Locus tag
    Dmel_CG1358
    See related
    AllianceGenome:FB:FBgn0033196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1358; Dmel\CG1358; hist
    Summary
    Enables histamine transmembrane transporter activity. Involved in histamine uptake. Located in plasma membrane. Is expressed in adult brain; adult fat body; and adult head. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to several human genes including FLVCR1 (FLVCR choline and heme transporter 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HisT in Genome Data Viewer
    Location:
    43E3-43E5; 2-57 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7595265..7620711, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3482770..3508216, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene scraps Neighboring gene long non-coding RNA:CR44444 Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Closer Look at Histamine in Drosophila. Volonté C, et al. Int J Mol Sci, 2024 Apr 18. PMID 38674034, Free PMC Article
    2. Drosophila HisT is a specific histamine transporter that contributes to histamine recycling in glia. Xie J, et al. Sci Adv, 2022 Oct 28. PMID 36288320, Free PMC Article
    3. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
    4. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
    5. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c7613604-7608472 mobile_element_type = transposon:I{}769

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histamine uptake IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histamine transporter
    Names
    CG1358-PA
    CG1358-PB
    CG1358-PC
    CG1358-PD
    FLVCR haem transporter
    HisT-PA
    HisT-PB
    HisT-PC
    HisT-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7595265..7620711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201944.2 → NP_001188873.1  histamine transporter, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1D7
      Conserved Domains (2) summary
      cd06174
      Location:63 → 461
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:62 → 422
      MFS_1; Major Facilitator Superfamily

    2. NM_165545.3 → NP_724584.1  histamine transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1D7
      Related
      FBpp0088023
      Conserved Domains (2) summary
      cd06174
      Location:63 → 461
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:62 → 422
      MFS_1; Major Facilitator Superfamily

    3. NM_136457.6 → NP_610301.1  histamine transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1D7
      Related
      FBpp0088022
      Conserved Domains (2) summary
      cd06174
      Location:63 → 461
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:62 → 422
      MFS_1; Major Facilitator Superfamily

    4. NM_165546.2 → NP_724585.1  histamine transporter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1D7
      Related
      FBpp0088024
      Conserved Domains (2) summary
      cd06174
      Location:63 → 461
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:62 → 422
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1D7 Q7K1D7

    Gene LinkOut

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