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    plum plum [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plumprovided by FlyBase
    Official Full Name
    plumprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039431
    Locus tag
    Dmel_CG6490
    See related
    AllianceGenome:FB:FBgn0039431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6490; CT20213; Dmel\CG6490; Plum
    Summary
    Predicted to enable cell adhesion molecule binding activity. Involved in negative regulation of synaptic assembly at neuromuscular junction and neuron remodeling. Located in axon and dendrite. Is expressed in brain; mushroom body; neuropil; and synaptic neuropil domain. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plum in Genome Data Viewer
    Location:
    97B4-97B9; 3-91 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26470078..26535217, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22295800..22360939, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46083 Neighboring gene long non-coding RNA:CR45226 Neighboring gene long non-coding RNA:CR46084 Neighboring gene scribble Neighboring gene long non-coding RNA:CR44951

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Sahota VK, et al. Open Biol, 2023 Sep. PMID 37699519, Free PMC Article
    2. Drosophila noktochor regulates night sleep via a local mushroom body circuit. Draper IR, et al. iScience, 2024 Mar 15. PMID 38380256, Free PMC Article
    3. Glial Derived TGF-β Instructs Axon Midline Stopping. Marmor-Kollet N, et al. Front Mol Neurosci, 2019. PMID 31611773, Free PMC Article
    4. A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster. Merenciano M, et al. Mob DNA, 2019. PMID 30911338, Free PMC Article
    5. Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling. Yu XM, et al. Neuron, 2013 May 8. PMID 23664613, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
      Title: Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plum
    Names
    CG6490-PB
    CG6490-PC
    CG6490-PD
    CG6490-PE
    plum-PB
    plum-PC
    plum-PD
    plum-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26470078..26535217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260388.1 → NP_001247317.1  plum, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVK2, H5ZV05, Q9VBE5
      Conserved Domains (4) summary
      smart00408
      Location:378 → 435
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:284 → 356
      IG_like; Immunoglobulin like
      cd00063
      Location:804 → 886
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:360 → 443
      I-set; Immunoglobulin I-set domain

    2. NM_001170273.2 → NP_001163744.1  plum, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVK2, H5ZV05, Q9VBE5
      Conserved Domains (4) summary
      smart00408
      Location:378 → 435
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:284 → 356
      IG_like; Immunoglobulin like
      cd00063
      Location:804 → 886
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:360 → 443
      I-set; Immunoglobulin I-set domain

    3. NM_143225.3 → NP_651482.3  plum, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651482.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVK2, H5ZV05, Q9VBE5
      Conserved Domains (4) summary
      smart00408
      Location:378 → 435
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:284 → 356
      IG_like; Immunoglobulin like
      cd00063
      Location:804 → 886
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:360 → 443
      I-set; Immunoglobulin I-set domain

    4. NM_001300615.1 → NP_001287544.1  plum, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVK2, H5ZV05, Q9VBE5
      Conserved Domains (4) summary
      smart00408
      Location:378 → 435
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:284 → 356
      IG_like; Immunoglobulin like
      cd00063
      Location:804 → 886
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:360 → 443
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T986 Q8T986
    Q9VBE5 Q9VBE5

    Gene LinkOut

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