U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Spn55B Serpin 55B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49803, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Spn55Bprovided by FlyBase
    Official Full Name
    Serpin 55Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028983
    Locus tag
    Dmel_CG10913
    See related
    AllianceGenome:FB:FBgn0028983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10913; Dmel\CG10913; sp-6; sp6; Sp6; spn55B; Spn6
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval gut; embryonic/larval salivary gland; garland cell primordium; and gut section. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive nonsyndromic deafness 91; and peeling skin syndrome 5. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB2 (serpin family B member 2); and SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Spn55B in Genome Data Viewer
    Location:
    55B7-55B7; 2-84 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18126347..18128210)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14013852..14015715)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene staufen Neighboring gene Dorsal interacting protein 3 Neighboring gene Heat shock factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
    2. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Richer MJ, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15247425, Free PMC Article
    3. Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. Nakaoka T, et al. PLoS One, 2017. PMID 28257485, Free PMC Article
    4. Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila. Katsukawa M, et al. Curr Biol, 2018 Jun 4. PMID 29804808
    5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serpin 55B
    Names
    CG10913-PA
    Spn55B-PA
    serine protease inhibitor 6
    serpin 6
    serpin55B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18126347..18128210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080214.4 → NP_524953.1  serpin 55B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV69
      Related
      FBpp0085912
      Conserved Domains (1) summary
      cd00172
      Location:13 → 370
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JV69 Q7JV69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous