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    Tsp42Ea Tetraspanin 42Ea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Eaprovided by FlyBase
    Official Full Name
    Tetraspanin 42Eaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029508
    Locus tag
    Dmel_CG18817
    See related
    AllianceGenome:FB:FBgn0029508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH05668; BcDNA:GM15292; CG18742; CG18817; CG3364; Dm.Tsp42Ea; Dmel\CG18817; GH05668; Q9U3V4
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; dorsal epidermis primordium; epithelium; and gut section. Orthologous to human TSPAN18 (tetraspanin 18) and TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42Ea in Genome Data Viewer
    Location:
    42E4-42E4; 2-55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6992676..7004259)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2880181..2891764)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene visceral mesodermal armadillo-repeats Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 42Eb Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 42Ec

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    2. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
    3. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. He L, et al. Elife, 2019 May 29. PMID 31140975, Free PMC Article
    4. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
    5. A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye. Anderson J, et al. Genetics, 2005 Dec. PMID 15998717, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42Ea
    Names
    CG18817-PA
    CG18817-PB
    CG18817-PC
    Tsp42Ea-PA
    Tsp42Ea-PB
    Tsp42Ea-PC
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6992676..7004259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080273.3 → NP_525012.2  tetraspanin 42Ea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525012.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1I4, Q9U3V4
      Related
      FBpp0085503
      Conserved Domains (2) summary
      cd03127
      Location:104 → 188
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 217
      Tetraspannin; Tetraspanin family

    2. NM_144389.2 → NP_652646.1  tetraspanin 42Ea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1I4, Q9U3V4
      Related
      FBpp0085504
      Conserved Domains (2) summary
      cd03127
      Location:104 → 188
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 217
      Tetraspannin; Tetraspanin family

    3. NM_165502.2 → NP_724524.1  tetraspanin 42Ea, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1I4, Q9U3V4
      Related
      FBpp0085505
      Conserved Domains (2) summary
      cd03127
      Location:104 → 188
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 217
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1I4 Q7K1I4
    Q8IH31 Q8IH31
    Q9U3V4 Q9U3V4

    Gene LinkOut

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