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    Cyp12b2 Cytochrome P450 12b2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp12b2provided by FlyBase
    Official Full Name
    Cytochrome P450 12b2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034387
    Locus tag
    Dmel_CG15077
    See related
    AllianceGenome:FB:FBgn0034387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12b2; CG15077; Cyp12B2; Dmel\CG15077
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp12b2 in Genome Data Viewer
    Location:
    55F1-55F1; 2-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18754995..18757083)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14642500..14644588)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jabba Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene Multiple C2 domain and transmembrane region protein Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene Regulatory Variation in Drosophila melanogaster Renal Tissue. Glaser-Schmitt A, et al. Genetics, 2018 Sep. PMID 29976765, Free PMC Article
    2. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
    3. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
    4. Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Giraudo M, et al. Pestic Biochem Physiol, 2010 Jun 1. PMID 20582327, Free PMC Article
    5. The molecular evolution of cytochrome P450 genes within and between drosophila species. Good RT, et al. Genome Biol Evol, 2014 Apr 20. PMID 24751979, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 12b2
    Names
    CG15077-PA
    Cyp12b2-PA
    NP_611370.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18754995..18757083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137526.3 → NP_611370.2  cytochrome P450 12b2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611370.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V474, Q9V8M2
      Conserved Domains (1) summary
      cl12078
      Location:59 → 511
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V8M2.2 Q9V8M2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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