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    Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [ Mus musculus (house mouse) ]

    Gene ID: 227446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Relchprovided by MGI
    Official Full Name
    RAB11 binding and LisH domain, coiled-coil and HEAT repeat containingprovided by MGI
    Primary source
    MGI:MGI:1922832
    See related
    Ensembl:ENSMUSG00000026319 AllianceGenome:MGI:1922832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1468; mKIAA1468; 6430401N10; 2310035C23Rik
    Summary
    Predicted to be involved in intracellular cholesterol transport. Located in recycling endosome. Is expressed in central nervous system and ganglia. Orthologous to human RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.9), bladder adult (RPKM 8.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Relch in Genome Data Viewer
    Location:
    1 E2.1; 1 49.64 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105591570..105682856)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105663843..105755131)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene 60S ribosomal protein L37a-like Neighboring gene STARR-positive B cell enhancer mm9_chr1:107527155-107527456 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:107559805-107559992 Neighboring gene STARR-positive B cell enhancer ABC_E988 Neighboring gene predicted gene 10193 Neighboring gene tumor necrosis factor receptor superfamily, member 11a, NFKB activator

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RAB11-binding protein RELCH
    Names
    RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029349.2NP_083625.1  RAB11-binding protein RELCH isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC101816, AC166354
      Consensus CDS
      CCDS48334.1
      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      A0A087WSS1
      Related
      ENSMUSP00000141162.2, ENSMUST00000190501.7
      Conserved Domains (1) summary
      sd00044
      Location:495527
      HEAT; HEAT repeat [structural motif]
    2. NM_173187.4NP_775279.2  RAB11-binding protein RELCH isoform 1

      See identical proteins and their annotated locations for NP_775279.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC101816, AC166354
      Consensus CDS
      CCDS15206.1
      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      E9QM90
      Related
      ENSMUSP00000039178.7, ENSMUST00000039173.13
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      105591570..105682856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529501.4XP_006529564.1  RAB11-binding protein RELCH isoform X1

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:10121040
      HEAT; HEAT repeat [structural motif]
    2. XM_006529507.4XP_006529570.1  RAB11-binding protein RELCH isoform X11

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:10121040
      HEAT; HEAT repeat [structural motif]
    3. XM_006529502.4XP_006529565.1  RAB11-binding protein RELCH isoform X2

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:648677
      HEAT; HEAT repeat [structural motif]
    4. XM_006529503.4XP_006529566.1  RAB11-binding protein RELCH isoform X3

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:10091037
      HEAT; HEAT repeat [structural motif]
    5. XM_006529504.4XP_006529567.1  RAB11-binding protein RELCH isoform X4

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:10081036
      HEAT; HEAT repeat [structural motif]
    6. XM_030253824.1XP_030109684.1  RAB11-binding protein RELCH isoform X12

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]
    7. XM_006529505.4XP_006529568.1  RAB11-binding protein RELCH isoform X5

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      G3X9J4
      Related
      ENSMUSP00000083926.5, ENSMUST00000086721.10
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]
    8. XM_036164603.1XP_036020496.1  RAB11-binding protein RELCH isoform X6

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]
    9. XM_030253811.1XP_030109671.1  RAB11-binding protein RELCH isoform X7

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]
    10. XM_036164608.1XP_036020501.1  RAB11-binding protein RELCH isoform X13

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519551
      HEAT; HEAT repeat [structural motif]
    11. XM_006529506.5XP_006529569.1  RAB11-binding protein RELCH isoform X8

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:9881016
      HEAT; HEAT repeat [structural motif]
    12. XM_030253819.1XP_030109679.1  RAB11-binding protein RELCH isoform X9

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:495527
      HEAT; HEAT repeat [structural motif]
    13. XM_036164606.1XP_036020499.1  RAB11-binding protein RELCH isoform X10

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:495527
      HEAT; HEAT repeat [structural motif]
    14. XM_036164611.1XP_036020504.1  RAB11-binding protein RELCH isoform X16

      Conserved Domains (1) summary
      sd00044
      Location:133165
      HEAT; HEAT repeat [structural motif]
    15. XM_036164609.1XP_036020502.1  RAB11-binding protein RELCH isoform X14

      Conserved Domains (1) summary
      sd00044
      Location:626654
      HEAT; HEAT repeat [structural motif]
    16. XM_036164610.1XP_036020503.1  RAB11-binding protein RELCH isoform X15

      Conserved Domains (1) summary
      sd00044
      Location:133165
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001784195.2 RNA Sequence

    2. XR_001784196.2 RNA Sequence

    3. XR_001784197.3 RNA Sequence

    4. XR_004942063.1 RNA Sequence

    5. XR_001784198.3 RNA Sequence

    6. XR_387169.4 RNA Sequence

      Related
      ENSMUST00000186807.7