Syt3 synaptotagmin III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt3provided by MGI
Official Full Name: synaptotagmin IIIprovided by MGI
Primary source: MGI:MGI:99665
See related: Ensembl:ENSMUSG00000030731 AllianceGenome:MGI:99665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sytIII
Summary: Enables calcium-dependent phospholipid binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in postsynapse. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 17.0), cortex adult (RPKM 9.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.83 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44032197..44049454)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44382773..44400030)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
Title: Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
Fast resupply of synaptic vesicles requires synaptotagmin-3.
Title: Fast resupply of synaptic vesicles requires synaptotagmin-3.
the combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility.
Title: Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:225321 (e-PCR)
- UniSTS:225321

AI385753 (e-PCR)
- UniSTS:179564

Syt3 (e-PCR), detects polymorphism
- UniSTS:507262

D1Bda19 (e-PCR)
- UniSTS:239766

RH94511 (e-PCR)
- UniSTS:119759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: synaptotagmin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114116.2 → NP_001107588.1 synaptotagmin-3

See identical proteins and their annotated locations for NP_001107588.1

Status: VALIDATED

Source sequence(s)

AC152939

Consensus CDS

CCDS21205.1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Related

ENSMUSP00000114070.2, ENSMUST00000118962.8

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
NM_001417323.1 → NP_001404252.1 synaptotagmin-3

Status: VALIDATED

Source sequence(s)

AC152939

UniProtKB/TrEMBL

G3X9Y1
NM_001417324.1 → NP_001404253.1 synaptotagmin-3

Status: VALIDATED

Source sequence(s)

AC152939

UniProtKB/TrEMBL

G3X9Y1
NM_001417325.1 → NP_001404254.1 synaptotagmin-3

Status: VALIDATED

Source sequence(s)

AC152939

UniProtKB/TrEMBL

G3X9Y1

Related

ENSMUSP00000112968.2, ENSMUST00000120262.2
NM_001417326.1 → NP_001404255.1 synaptotagmin-3

Status: VALIDATED

Source sequence(s)

AC152939

UniProtKB/TrEMBL

G3X9Y1
NM_016663.4 → NP_057872.3 synaptotagmin-3

See identical proteins and their annotated locations for NP_057872.3

Status: VALIDATED

Source sequence(s)

AC152939

Consensus CDS

CCDS21205.1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Related

ENSMUSP00000112432.2, ENSMUST00000118831.8

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

44032197..44049454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242318.1 → XP_030098178.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_036152863.1 → XP_036008756.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_017322088.1 → XP_017177577.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_017322089.1 → XP_017177578.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_030242319.1 → XP_030098179.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_036152864.1 → XP_036008757.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_017322087.2 → XP_017177576.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
XM_030242317.2 → XP_030098177.1 synaptotagmin-3 isoform X1

UniProtKB/Swiss-Prot

O35681, P97791, Q80WV1

UniProtKB/TrEMBL

G3X9Y1

Conserved Domains (2) summary

cd08385
Location:297 → 421

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08403
Location:430 → 564

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10