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    Lrrfip2 LRR binding FLII interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrfip2provided by RGD
    Official Full Name
    LRR binding FLII interacting protein 2provided by RGD
    Primary source
    RGD:1306234
    See related
    EnsemblRapid:ENSRNOG00000021047 AllianceGenome:RGD:1306234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable LRR domain binding activity. Predicted to be involved in Wnt signaling pathway and regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of gene expression and toll-like receptor signaling pathway. Orthologous to human LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 310.8), Testes (RPKM 188.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrfip2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119969908..120071270)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (111091453..111193947)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119381666..119484125)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094383 Neighboring gene uncharacterized LOC102552504 Neighboring gene mutL homolog 1 Neighboring gene EPM2A interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. Fong KS, et al. Genomics, 1999 Jun 1. PMID 10366446
    2. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. Dai P, et al. J Immunol, 2009 Mar 15. PMID 19265123
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MyD88-dependent toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within MyD88-independent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 2
    Names
    LRR FLII-interacting protein 2
    leucine rich repeat (in FLII) interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024761.1 → NP_001019932.1  leucine-rich repeat flightless-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001019932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC097955
      UniProtKB/Swiss-Prot
      Q4V7E8
      UniProtKB/TrEMBL
      A0A8I5ZMY2
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 362
      LRRFIP; LRRFIP family
      pfam11932
      Location:378 → 437
      DUF3450; Protein of unknown function (DUF3450)

    2. NM_001395739.1 → NP_001382668.1  leucine-rich repeat flightless-interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZMY2
      Related
      ENSRNOP00000079448.2, ENSRNOT00000100197.2
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 349
      LRRFIP; LRRFIP family
      pfam11932
      Location:365 → 424
      DUF3450; Protein of unknown function (DUF3450)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119969908..120071270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766619.3 → XP_008764841.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764841.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463 → 585
      MreC; rod shape-determining protein MreC

    2. XM_063265276.1 → XP_063121346.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

      UniProtKB/TrEMBL
      A6I3J0

    3. XM_063265279.1 → XP_063121349.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

      UniProtKB/TrEMBL
      A6I3J0

    4. XM_063265288.1 → XP_063121358.1  leucine-rich repeat flightless-interacting protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A8I5ZMY2

    5. XM_063265281.1 → XP_063121351.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

      UniProtKB/TrEMBL
      A6I3J0

    6. XM_063265287.1 → XP_063121357.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

    7. XM_063265285.1 → XP_063121355.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

    8. XM_063265292.1 → XP_063121362.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I5ZQP7

    9. XM_063265291.1 → XP_063121361.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

    10. XM_008766616.4 → XP_008764838.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764838.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Related
      ENSRNOP00000082163.1, ENSRNOT00000108084.2
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463 → 585
      MreC; rod shape-determining protein MreC

    11. XM_008766625.4 → XP_008764847.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (3) summary
      pfam09738
      Location:319 → 639
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cd16269
      Location:493 → 504
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:369 → 504
      GBP_C; Guanylate-binding protein, C-terminal domain

    12. XM_017595600.3 → XP_017451089.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLX7

    13. XM_006243939.4 → XP_006244001.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AUZ7, A0A8I6GLX7
      Related
      ENSRNOP00000097455.1, ENSRNOT00000112179.2
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 608
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam17031
      Location:375 → 431
      DUF5101; Domain of unknown function (DUF5101)

    14. XM_008766623.3 → XP_008764845.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 649
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:439 → 561
      MreC; rod shape-determining protein MreC

    15. XM_039081260.2 → XP_038937188.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 615
      LRRFIP; LRRFIP family
      pfam11932
      Location:631 → 690
      DUF3450; Protein of unknown function (DUF3450)

    16. XM_039081259.2 → XP_038937187.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 618
      LRRFIP; LRRFIP family
      pfam11932
      Location:634 → 693
      DUF3450; Protein of unknown function (DUF3450)

    17. XM_063265272.1 → XP_063121342.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6GLX7

    18. XM_008766624.4 → XP_008764846.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:289 → 643
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:433 → 555
      MreC; rod shape-determining protein MreC

    19. XM_039081261.2 → XP_038937189.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:289 → 612
      LRRFIP; LRRFIP family
      pfam11932
      Location:628 → 687
      DUF3450; Protein of unknown function (DUF3450)

    20. XM_039081271.2 → XP_038937199.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

      Conserved Domains (2) summary
      pfam09738
      Location:138 → 492
      LRRFIP; LRRFIP family
      pfam11932
      Location:508 → 567
      DUF3450; Protein of unknown function (DUF3450)

    21. XM_063265277.1 → XP_063121347.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZMY2

    22. XM_063265273.1 → XP_063121343.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

    23. XM_063265280.1 → XP_063121350.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZMY2

    24. XM_039081272.2 → XP_038937200.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 469
      LRRFIP; LRRFIP family
      pfam11932
      Location:485 → 544
      DUF3450; Protein of unknown function (DUF3450)

    25. XM_063265275.1 → XP_063121345.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

      UniProtKB/TrEMBL
      A6I3J0

    26. XM_063265274.1 → XP_063121344.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

      UniProtKB/TrEMBL
      A6I3J0

    27. XM_063265278.1 → XP_063121348.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

      UniProtKB/TrEMBL
      A6I3J0

    28. XM_008766626.3 → XP_008764848.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A2V6
      Related
      ENSRNOP00000079352.2, ENSRNOT00000119180.2
      Conserved Domains (2) summary
      pfam09738
      Location:279 → 633
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:423 → 545
      MreC; rod shape-determining protein MreC

    29. XM_039081273.2 → XP_038937201.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 452
      LRRFIP; LRRFIP family
      pfam11932
      Location:468 → 527
      DUF3450; Protein of unknown function (DUF3450)

    30. XM_063265282.1 → XP_063121352.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I6AJ95

    31. XM_063265284.1 → XP_063121354.1  leucine-rich repeat flightless-interacting protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZMY2

    32. XM_039081277.2 → XP_038937205.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 429
      LRRFIP; LRRFIP family
      pfam11932
      Location:445 → 504
      DUF3450; Protein of unknown function (DUF3450)

    33. XM_008766628.4 → XP_008764850.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A2V6
      Related
      ENSRNOP00000091298.2, ENSRNOT00000099949.2
      Conserved Domains (2) summary
      pfam09738
      Location:264 → 618
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:408 → 530
      MreC; rod shape-determining protein MreC

    34. XM_039081281.2 → XP_038937209.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 414
      LRRFIP; LRRFIP family
      pfam11932
      Location:430 → 489
      DUF3450; Protein of unknown function (DUF3450)

    35. XM_063265283.1 → XP_063121353.1  leucine-rich repeat flightless-interacting protein 2 isoform X27

      UniProtKB/TrEMBL
      A6I3J0

    36. XM_039081283.2 → XP_038937211.1  leucine-rich repeat flightless-interacting protein 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I6A6N0, A6I3J0

    37. XM_039081282.2 → XP_038937210.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 390
      LRRFIP; LRRFIP family
      pfam11932
      Location:406 → 465
      DUF3450; Protein of unknown function (DUF3450)

    38. XM_063265286.1 → XP_063121356.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

    39. XM_039081285.2 → XP_038937213.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

    40. XM_006243960.3 → XP_006244022.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I5ZQP7
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 325
      LRRFIP; LRRFIP family
      pfam11932
      Location:341 → 400
      DUF3450; Protein of unknown function (DUF3450)

    41. XM_039081286.2 → XP_038937214.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 336
      LRRFIP; LRRFIP family
      pfam11932
      Location:352 → 411
      DUF3450; Protein of unknown function (DUF3450)

    42. XM_063265296.1 → XP_063121366.1  leucine-rich repeat flightless-interacting protein 2 isoform X39

    43. XM_063265295.1 → XP_063121365.1  leucine-rich repeat flightless-interacting protein 2 isoform X38

    44. XM_008766618.4 → XP_008764840.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764840.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463 → 585
      MreC; rod shape-determining protein MreC

    45. XM_008766617.4 → XP_008764839.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764839.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463 → 585
      MreC; rod shape-determining protein MreC

    46. XM_039081284.2 → XP_038937212.1  leucine-rich repeat flightless-interacting protein 2 isoform X28

      Conserved Domains (2) summary
      pfam09738
      Location:10 → 364
      LRRFIP; LRRFIP family
      pfam11932
      Location:380 → 439
      DUF3450; Protein of unknown function (DUF3450)

    47. XM_063265290.1 → XP_063121360.1  leucine-rich repeat flightless-interacting protein 2 isoform X33

    48. XM_063265293.1 → XP_063121363.1  leucine-rich repeat flightless-interacting protein 2 isoform X36

    49. XM_063265294.1 → XP_063121364.1  leucine-rich repeat flightless-interacting protein 2 isoform X37

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7E8.1 GenPept UniProtKB/Swiss-Prot:Q4V7E8

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