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    Gabrp gamma-aminobutyric acid type A receptor subunit pi [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabrpprovided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit piprovided by RGD
    Primary source
    RGD:620532
    See related
    EnsemblRapid:ENSRNOG00000032417 AllianceGenome:RGD:620532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-gated chloride ion channel activity. Contributes to GABA-A receptor activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Located in plasma membrane. Orthologous to human GABRP (gamma-aminobutyric acid type A receptor subunit pi). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.8), Uterus (RPKM 46.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabrp in Genome Data Viewer
    Location:
    10q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (18647243..18673806, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18143031..18169595, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18484257..18510604, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 17 Neighboring gene T-cell leukemia, homeobox 3 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene uncharacterized LOC108352198 Neighboring gene uncharacterized LOC120095244 Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene large ribosomal subunit protein eL8-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel function of ionotropic gamma-aminobutyric acid receptors involving alveolar fluid homeostasis. Jin N, et al. J Biol Chem, 2006 Nov 24. PMID 17003036
    2. Identification of two novel markers for alveolar epithelial type I and II cells. Chen Z, et al. Biochem Biophys Res Commun, 2004 Jul 2. PMID 15184050
    3. A novel class of GABAA receptor subunit in tissues of the reproductive system. Hedblom E, et al. J Biol Chem, 1997 Jun 13. PMID 9182563
    4. Novel hepatic progenitor cell surface markers in the adult rat liver. Yovchev MI, et al. Hepatology, 2007 Jan. PMID 17187413
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GABA-A receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GABA-gated chloride ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GABA-gated chloride ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit pi
    Names
    GABA(A) receptor subunit pi
    GABA-A receptor pi subunit
    GABAAR subunit pi
    gamma-aminobutyric acid (GABA-A) receptor, pi
    gamma-aminobutyric acid A receptor, pi
    gamma-aminobutyric acid type A receptor pi subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031029.2 → NP_112291.1  gamma-aminobutyric acid receptor subunit pi precursor

      See identical proteins and their annotated locations for NP_112291.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O09028
      UniProtKB/TrEMBL
      F1LM27
      Related
      ENSRNOP00000048081.6, ENSRNOT00000043036.7
      Conserved Domains (3) summary
      TIGR00860
      Location:43 → 437
      LIC; Cation transporter family protein
      cd03558
      Location:159 → 174
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:60 → 241
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      18647243..18673806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086934.2 → XP_038942862.1  gamma-aminobutyric acid receptor subunit pi isoform X1

      Conserved Domains (4) summary
      cd03558
      Location:159 → 174
      LGIC_ECD; Cys-loop [structural motif]
      cd03559
      Location:244 → 267
      LGIC_TM; TM1 helix [structural motif]
      cl28912
      Location:60 → 241
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
      cl38911
      Location:243 → 280
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09028.1 GenPept UniProtKB/Swiss-Prot:O09028

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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