Srxn1 sulfiredoxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srxn1provided by RGD
Official Full Name: sulfiredoxin 1provided by RGD
Primary source: RGD:1307332
See related: AllianceGenome:RGD:1307332
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Npn3; Ab2-390
Summary: Predicted to enable oxidoreductase activity, acting on a sulfur group of donors. Predicted to be involved in response to oxidative stress. Predicted to be located in cytosol. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 94.8), Thymus (RPKM 48.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (161064812..161070372)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140604490..140610050)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147608850..147614410)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammatory response and oxidative stress attenuated by sulfiredoxin1 in neuronlike cells depends on nuclear factor erythroid2related factor 2.
Title: Inflammatory response and oxidative stress attenuated by sulfiredoxin‑1 in neuron‑like cells depends on nuclear factor erythroid‑2‑related factor 2.
Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation/reoxygenation model through the bax/cytochrome c/caspase 3 apoptosis pathway.
Title: Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation/reoxygenation model through the bax/cytochrome c/caspase 3 apoptosis pathway.
Results suggest that Srxn1 can protect neurons from ischemia/reperfusion oxidative stress injury, and the underlying mechanism involves Prdxs activity. Srxn1, which might be a downstream gene of Nrf2, can resist cerebral ischemia and reperfusion by reversing overoxidized Prdx and restoring antioxidant activity of Prdx.
Title: Neuroprotective effects of sulfiredoxin-1 during cerebral ischemia/reperfusion oxidative stress injury in rats.
these results suggested that Srx-1 might protect cardiomyocyte injury upon SI/R by suppressing PI3K/AKT-mediated mitochondria dependent apoptosis, revealing a promising therapeutic agent against ischaemic cardiovascular diseases.
Title: Sulfiredoxin-1 protects against simulated ischaemia/reperfusion injury in cardiomyocyte by inhibiting PI3K/AKT-regulated mitochondrial apoptotic pathways.
Srxn1 protects primary rat cortical astrocytes from oxygen-glucose deprivation- or H2O2-induced apoptosis and that involves the activation of the mitochondrial apoptotic pathway.
Title: Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide.
Srxn1 knockdown by two shRNAs decreased cell viability of astrocytes and correlated with excessive levels of proinflammatory cytokines and chemokines. It influences the strength of TLR4 signaling pathway.
Title: Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage.
Nrf2 upregulated Srxn1 expression during oxidative stress in astrocytes.
Title: Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes.
Srxn1 play a protective role against oxidative injury
Title: Sulfiredoxin-1 protects PC12 cells against oxidative stress induced by hydrogen peroxide.
Sulfiredoxin induction is dependent on c-Jun expression and mediates brain-derived neurotrophic factor (BDNF) protection against mitochondrial inhibition.
Title: c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons.
the importance of histone acetylation in the regulation of Srxn1 and Sesn2, to understand more about how these genes are regulated by synaptic activity was investigated.
Title: Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on a sulfur group of donors	ISO Inferred from Sequence Orthology more info
enables sulfiredoxin activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfiredoxin-1

Names: neoplastic progression 3

NP_001041323.3

EC 1.8.98.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.