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    C12h7orf50 similar to human chromosome 7 open reading frame 50 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498154, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C12h7orf50provided by RGD
    Official Full Name
    similar to human chromosome 7 open reading frame 50provided by RGD
    Primary source
    RGD:1566418
    See related
    AllianceGenome:RGD:1566418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C7orf50
    Summary
    Predicted to enable hormone activity. Predicted to be involved in negative regulation of cholesterol biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human C7orf50 (chromosome 7 open reading frame 50). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 42.1), Lung (RPKM 38.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C12h7orf50 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20298968..20402890)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15185728..15289042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17277635..17380497)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 12 Neighboring gene zinc finger AN1-type containing 2A Neighboring gene RIKEN cDNA C130050O18 gene like Neighboring gene G protein-coupled estrogen receptor 1 Neighboring gene G protein-coupled receptor 146 Neighboring gene microRNA 339 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1 Neighboring gene cytochrome c oxidase assembly factor COX19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cholesin; uncharacterized protein C7orf50 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025033.1 → NP_001020204.1  cholesin

      See identical proteins and their annotated locations for NP_001020204.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088429
      UniProtKB/Swiss-Prot
      Q5I0E3
      UniProtKB/TrEMBL
      A6K1V5
      Conserved Domains (1) summary
      pfam10180
      Location:103 → 163
      DUF2373; uncharacterized conserved protein (DUF2373)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      20298968..20402890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271577.1 → XP_063127647.1  uncharacterized protein C7orf50 homolog isoform X1

    2. XM_063271578.1 → XP_063127648.1  uncharacterized protein C7orf50 homolog isoform X3

    3. XM_063271582.1 → XP_063127652.1  uncharacterized protein C7orf50 homolog isoform X5

    4. XM_063271579.1 → XP_063127649.1  uncharacterized protein C7orf50 homolog isoform X4

    5. XM_063271581.1 → XP_063127651.1  uncharacterized protein C7orf50 homolog isoform X5

    6. XM_006248959.5 → XP_006249021.2  uncharacterized protein C7orf50 homolog isoform X2

      Conserved Domains (1) summary
      pfam10180
      Location:69 → 130
      DUF2373; Uncharacterized conserved protein (DUF2373)

    7. XM_063271580.1 → XP_063127650.1  uncharacterized protein C7orf50 homolog isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0E3.1 GenPept UniProtKB/Swiss-Prot:Q5I0E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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