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    higA antitoxin HigA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885964, updated on 6-Jun-2024

    Summary

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    Gene symbol
    higA
    Gene description
    antitoxin HigA
    Locus tag
    Rv1956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2202138..2202587)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene antitoxin VapB14 Neighboring gene ribonuclease VapC14 Neighboring gene hypothetical protein Neighboring gene toxin HigB Neighboring gene SecB-like chaperone Neighboring gene hypothetical protein Neighboring gene toxin ParE1 Neighboring gene antitoxin ParD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Schuessler DL, et al. Mol Microbiol, 2013 Oct. PMID 23927792, Free PMC Article
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors show that expression of HigB toxin in the absence of HigA antitoxin arrests growth and causes cell death in Mycobacterium tuberculosis.
      Title: Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    antitoxin HigA
    NP_216472.1
    • part of toxin-antitoxin (TA) operon with Rv1955. Upon expression in E.coli Rv1956 has been shown to function as a toxin inhibiting cell growth and colony formation that is neutralized by coexpression with Rv1955 (PubMed: 19016878); It is not clear if these conflicting results are due to expression in a heterologous system. The gene names higA and higB have been assigned to both Rv1955 and Rv1956; we have chosen to call Rv1956 higA after consulting the authors.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2202138..2202587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216472.1 antitoxin HigA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216472.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A9P2H894
      Conserved Domains (1) summary
      cd00093
      Location:40 → 90
      HTH_XRE; Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WJA7.1

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