U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rv1747 ABC transporter ATP-binding protein/permease [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885311, updated on 4-Feb-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    Rv1747
    Gene description
    ABC transporter ATP-binding protein/permease
    Locus tag
    Rv1747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (1973630..1976227)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene isopentenyl-diphosphate delta-isomerase Neighboring gene serine/threonine-protein kinase PknF Neighboring gene hypothetical protein Neighboring gene integral membrane protein Neighboring gene fatty-acid--CoA ligase FadD1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis. Heinkel F, et al. Proc Natl Acad Sci U S A, 2019 Aug 13. PMID 31366629, Free PMC Article
    2. Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747. Heinkel F, et al. Structure, 2018 Jul 3. PMID 29861345
    3. Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis. Spivey VL, et al. J Biol Chem, 2011 Jul 22. PMID 21622570, Free PMC Article
    4. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth. Glass LN, et al. PLoS Pathog, 2017 Jul. PMID 28753640, Free PMC Article
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we demonstrate that the regulatory modules of Rv1747 and its homolog in Mycobacterium smegmatis form liquid-like condensates as a function of concentration and phosphorylation. The serine/threonine kinases and sole phosphatase of Mtb tune phosphorylation-enhanced phase separation and differentially colocalize with the resulting condensates
      Title: Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis.
    2. Results show that Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting Forkhead-associated (FHA) domain connected by an ID linker string. In contrast to the well-ordered domains, the unmodified linker is conformationally disordered. When joined within a polypeptide chain, either FHA domain can bind either linker pThr to form intra- and intermolecular complexes.
      Title: Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747.
    3. Rv2623 interacts with one of the two forkhead-associated domains (FHA I) of Rv1747 to regulate mycobacterial growth.
      Title: Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.
    4. molecular mechanism(s) regulating Rv1747 through PknF-dependent phosphorylation
      Title: Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    ABC transporter ATP-binding protein/permease

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1973630..1976227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216263.1 ABC transporter ATP-binding protein/permease [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216263.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E7X008, Q7D814, R4MGX2
      Conserved Domains (5) summary
      COG1131
      Location:319 → 540
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      COG1716
      Location:157 → 332
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      TIGR00955
      Location:290 → 864
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam00498
      Location:29 → 91
      FHA; FHA domain
      pfam15240
      Location:94 → 185
      Pro-rich; Proline-rich
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65934.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases