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    embB arabinosyltransferase B [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886126, updated on 6-Oct-2023

    Summary

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    Gene symbol
    embB
    Gene description
    arabinosyltransferase B
    Locus tag
    Rv3795
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (4246514..4249810)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene decaprenylphosphoryl-D-2-keto erythropentose reductase Neighboring gene arabinofuranosyltransferase Neighboring gene arabinosyltransferase C Neighboring gene arabinosyltransferase A Neighboring gene hypothetical protein Neighboring gene acyl-CoA dehydrogenase FadE35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of association of novel mutation Asp397Gly in aftB gene with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis. Giri A, et al. Tuberculosis (Edinb), 2019 Mar. PMID 30948176
    2. Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland. Bakuła Z, et al. Biomed Res Int, 2013. PMID 24392447, Free PMC Article
    3. Correlation of the phenotypic ethambutol susceptibility of Mycobacterium tuberculosis with embB gene mutations in Korea. Park YK, et al. J Med Microbiol, 2012 Apr. PMID 22174373
    4. Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China. Shi D, et al. J Antimicrob Chemother, 2011 Oct. PMID 21778195, Free PMC Article
    5. embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation. Plinke C, et al. J Antimicrob Chemother, 2010 Jul. PMID 20427375

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors conclude, though aftBAsp397Gly mutation is not associated with EMB resistance, this mutation may be a phylogenetic marker for the Beijing clade.
      Title: Lack of association of novel mutation Asp397Gly in aftB gene with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis.
    2. association between embB mutations and resistance to Ethambutol(EMB): mutations in codon 306 were most common, found in both EMB-resistant (9) and EMB-susceptible (11) isolates
      Title: Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland.
    3. The ethambutol resistance of M. TB strains isolated from patients in Xi'an is related to the mutation of embB gene.
      Title: [Correlation between ethambutol-resistance and embB gene mutation in Mycobacterium tuberculosis].
    4. embB mutation except for a few specific mutation types may be the main cause of EMB resistance.
      Title: Correlation of the phenotypic ethambutol susceptibility of Mycobacterium tuberculosis with embB gene mutations in Korea.
    5. results suggest embB mutations alone are not sufficient for the development of full resistance to ethambutol in M. tuberculosis and mutations other than embB are also needed.
      Title: Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China.
    6. mutations in embB306, embB406 and embB497 were confirmed as hot spots for genomic variation in ethambutol-resistant clinical isolates
      Title: embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation.
    7. Drug resistance in M tuberculosis is due to mutations in relatively restricted regions of the genome: rpoB for RIF, katG and inhA for INH, embB for ethambutol, pncA for pyrazinamide, and so on.
      Title: Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting.
    8. A statistical significant association was found between the frequency of embB306 mutations and the multidrug resistant phenotype.
      Title: [Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains].
    9. embB 306 mutations are sufficient to confer ethambutol resistance, and detection of these mutations should be considered in the development of rapid molecular tests
      Title: Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis.
    10. The PknH-mediated increase in the transcription of embAB genes significantly alters resistance to ethambutol, a frontline antituberculosis drug known to target embAB genes.
      Title: Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
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    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    arabinosyltransferase B
    NP_218312.1
    • EmbB (arabinosylindolylacetylinositol synthase)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4246514..4249810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218312.1 arabinosyltransferase B [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218312.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024CBA5, A0A024CBD2, A0A024CBG6, A0A097KUD1, A0A0B5HFG7, A0A5B8GS92
      Conserved Domains (3) summary
      pfam04602
      Location:214 → 688
      Arabinose_trans; Mycobacterial cell wall arabinan synthesis protein
      pfam14896
      Location:720 → 1095
      Arabino_trans_C; EmbC C-terminal domain
      pfam17689
      Location:51 → 209
      Arabino_trans_N; Arabinosyltransferase concanavalin like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WNL7.1

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