U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    embC arabinosyltransferase C [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886112, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    embC
    Gene description
    arabinosyltransferase C
    Locus tag
    Rv3793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (4239863..4243147)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene decaprenylphosphoryl-beta-D-ribose oxidase Neighboring gene decaprenylphosphoryl-D-2-keto erythropentose reductase Neighboring gene arabinofuranosyltransferase Neighboring gene arabinosyltransferase A Neighboring gene arabinosyltransferase B Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan. Korkegian A, et al. J Biol Chem, 2014 Dec 19. PMID 25352598, Free PMC Article
    2. The critical role of embC in Mycobacterium tuberculosis. Goude R, et al. J Bacteriol, 2008 Jun. PMID 18424526, Free PMC Article
    3. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. Sharma K, et al. J Bacteriol, 2006 Apr. PMID 16585755, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that loss of asparagine Asn-638 in arabinosyltransferase EmbC resulted in the synthesis of truncated lipoarabinomannan (LAM).
      Title: Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.
    2. Results have identified embC as the key genes involved in LAM biosynthesis in M. tuberculosis and confirmed its essential role in this species.
      Title: The critical role of embC in Mycobacterium tuberculosis.
    3. increased transcription of embC, catalyzing arabinosylation of lipomannan (LM) to lipoarabinomannan (LAM), results in a high LAM/LM ratio, which in turn is a crucial factor in mycobacterial virulence.
      Title: Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    arabinosyltransferase C
    NP_218310.1
    • EmbC (arabinosylindolylacetylinositol synthase)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4239863..4243147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218310.1 arabinosyltransferase C [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218310.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024CBH6, A0A0B5HBJ2, A0A0B5HFG2, A0A0B5HP58, A0A0B5HSY1, A0A0G3VTF1
      Conserved Domains (3) summary
      pfam04602
      Location:225 → 681
      Arabinose_trans; Mycobacterial cell wall arabinan synthesis protein
      pfam14896
      Location:721 → 1092
      Arabino_trans_C; EmbC C-terminal domain
      pfam17689
      Location:53 → 221
      Arabino_trans_N; Arabinosyltransferase concanavalin like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WNL5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases