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    relA bifunctional (p)ppGpp synthase/hydrolase RelA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887888, updated on 6-Aug-2024

    Summary

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    Gene symbol
    relA
    Gene description
    bifunctional (p)ppGpp synthase/hydrolase RelA
    Locus tag
    Rv2583c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2907826..2910198, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene histidine--tRNA ligase Neighboring gene glyoxalase II Neighboring gene peptidyl-prolyl cis-trans isomerase B Neighboring gene adenine phosphoribosyltransferase Neighboring gene lipoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design. Hegde V, et al. Protein Expr Purif, 2021 Jan. PMID 33002609
    2. Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis. Avarbock A, et al. Biochemistry, 2005 Jul 26. PMID 16026164
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design.
      Title: Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design.
    2. Purified functional synthesis and hydrolysis fragments of bifunctional RelA demonstrate distinct active sites; RelA carboxyl-terminus is an important region for multimerization and regulation of (p)ppGpp synthesis and hydrolysis
      Title: Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    bifunctional (p)ppGpp synthase/hydrolase RelA
    NP_217099.1
    • ATP:GTP 3'-pyrophosphotransferase (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2907826..2910198 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217099.1 bifunctional (p)ppGpp synthase/hydrolase RelA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217099.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0U0QHY2
      Conserved Domains (1) summary
      TIGR00691
      Location:86 → 785
      spoT_relA; (p)ppGpp synthetase, RelA/SpoT family
    Nucleotide Protein
    Heading Accession and Version

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